ChemicalBook > CAS DataBase List > 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID

1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID

Product Name
1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
CAS No.
1001754-59-1
Chemical Name
1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
Synonyms
1-Boc-3-fluoropyrrolidine-3-carboxylic acid;1-Boc-3-fluoropyrrolidine-3-carboxylic acid - [F14430];1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID;1-[(tert-butoxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic a...;1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(1,1-dimethylethyl) ester;3-FLUORO-1-[(2-METHYLPROPAN-2-YL)OXYCARBONYL]PYRROLIDINE-3-CARBOXYLIC ACID
CBNumber
CB7787227
Molecular Formula
C10H16FNO4
Formula Weight
233.24
MOL File
Mol file
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1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Property

Melting point:
140-142 °C
Boiling point:
330℃
Density 
1.25
Flash point:
153℃
storage temp. 
2-8°C
pka
2.38±0.20(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D6507
Product name
1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic Acid
Purity
min. 98.0 %
Packaging
200MG
Price
$192
Updated
2025/07/31
TRC
Product number
B810953
Product name
1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylicAcid
Packaging
50mg
Price
$130
Updated
2021/12/16
AK Scientific
Product number
4918AQ
Product name
3-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylicacid
Packaging
100mg
Price
$201.2
Updated
2021/12/16
Synthonix
Product number
F14430
Product name
1-Boc-3-fluoropyrrolidine-3-carboxylicacid
Purity
97.0%
Packaging
1g
Price
$460
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0062288
Product name
1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
Purity
95.00%
Packaging
1G
Price
$722.4
Updated
2021/12/16
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1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

942189-96-0

1001754-59-1

Step 3: 1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate (414.4 mg, 1.676 mmol) was dissolved in a 3:1 THF/MeOH solvent mixture (5.6 mL), and 2.0 M KOH aqueous solution (2.1 mL, 4.19 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the organic solvent was removed by distillation under reduced pressure. The residue was diluted with 20% isopropanol/dichloromethane (IPA/DCM) mixed solvent and subsequently acidified to pH 3 with 1.0 M aqueous HCl. The resulting mixture was extracted twice with 20% IPA/DCM mixed solvent, the organic phases were combined, washed twice with water, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid ( 352.8 mg, 90.3% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ= 13.80 (s, 1H), 3.69-3.54 (m, 3H), 3.36-3.32 (m, 1H), 2.43-2.24 (m, 2H), 1.40 (s, 9H).

References

[1] Patent: WO2013/20062, 2013, A1. Location in patent: Paragraph 00244
[2] Patent: WO2018/178041, 2018, A1. Location in patent: Page/Page column 116; 117

1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID Suppliers

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1001754-59-1, 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACIDRelated Search:

(R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid 1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(9H-fluoren-9-ylmethyl) ester (3S)-1-[(tert-butoxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic acid

  • 1-(TERT-BUTOXYCARBONYL)-3-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID
  • 1-Boc-3-fluoropyrrolidine-3-carboxylic acid
  • 1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(1,1-dimethylethyl) ester
  • 3-FLUORO-1-[(2-METHYLPROPAN-2-YL)OXYCARBONYL]PYRROLIDINE-3-CARBOXYLIC ACID
  • 1-[(tert-butoxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic a...
  • 1-Boc-3-fluoropyrrolidine-3-carboxylic acid - [F14430]
  • 1001754-59-1