BRD5648

Product Name: BRD5648
CAS No.: 2056261-42-6
Chemical Name: BRD5648
Synonyms: BRD5648;(R)-BRD0705;BRD5648, 10 mM in DMSO;(4R)-4-Ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one;5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-, (4R)-;compound,Glycogen synthase kinase 3,negative,Glycogen synthase kinase-3,BRD-5648,GSK-3,BRD5648,inhibit,BRD 5648,Inhibitor,(R)-enantiomer,control
CBNumber: CB78024432
Molecular Formula: C20H23N3O
Formula Weight: 321.42
MOL File: 2056261-42-6.mol

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BRD5648 Property

Boiling point:: 512.0±50.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
pka: 14.82±0.60(Predicted)
form: Solid
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem

Product number: Axon3153
Product name: BRD5648
Purity: 99%
Packaging: 5mg
Price: $231
Updated: 2021/12/16

ChemScene

Product number: CS-0114013
Product name: BRD5648
Purity: 97.07%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0114013
Product name: BRD5648
Purity: 97.07%
Packaging: 10mg
Price: $1050
Updated: 2021/12/16

ChemScene

Product number: CS-0114013
Product name: BRD5648
Purity: 97.07%
Packaging: 50mg
Price: $2950
Updated: 2021/12/16

ChemScene

Product number: CS-0114013
Product name: BRD5648
Purity: 97.07%
Packaging: 100mg
Price: $4950
Updated: 2021/12/16

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BRD5648 Chemical Properties,Usage,Production

Description

BRD5648 is an inactive (R)-enantiomer of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor. It can be used for acute myeloid leukemia (AML).

Uses

BRD5648 ((R)-BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].

References

[1] Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. DOI:10.1126/scitranslmed.aam8460

BRD5648 Preparation Products And Raw materials

Raw materials

Preparation Products

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BRD5648 Suppliers

China 15 United States 4 Global 19

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2056261-42-6, BRD5648Related Search:

BRD5648

(R)-BRD0705

compound,Glycogen synthase kinase 3,negative,Glycogen synthase kinase-3,BRD-5648,GSK-3,BRD5648,inhibit,BRD 5648,Inhibitor,(R)-enantiomer,control

5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-, (4R)-

BRD5648, 10 mM in DMSO

(4R)-4-Ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one

2056261-42-6