Ly93
- Product Name
- Ly93
- CAS No.
- 1883528-69-5
- Chemical Name
- Ly93
- Synonyms
- Ly93;Ly93,Ly-93;SMS2-IN-Ly93;Ly93, 10 mM in DMSO;Benzamide, 2-[(2-ethylphenyl)methoxy]-N-3-pyridinyl-;2-[(2-ethylphenyl)methoxy]-N-(pyridin-3-yl)benzamide
- CBNumber
- CB78054633
- Molecular Formula
- C21H20N2O2
- Formula Weight
- 332.4
- MOL File
- 1883528-69-5.mol
Ly93 Property
- Boiling point:
- 450.6±35.0 °C(Predicted)
- Density
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 250 mg/mL (752.11 mM; Need ultrasonic)
- pka
- 12.67±0.70(Predicted)
- form
- Solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
Ly93 Chemical Properties,Usage,Production
Biological Activity
Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1]. Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].
References
[1]. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.
Ly93 Preparation Products And Raw materials
Raw materials
Preparation Products
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