Biotin-PEG4-amino-t-Bu-DADPS-C6-azide

Product Name: Biotin-PEG4-amino-t-Bu-DADPS-C6-azide
CAS No.: 1260247-50-4
Chemical Name: Biotin-PEG4-amino-t-Bu-DADPS-C6-azide
Synonyms: DADPS Biotin Azide;DADPS Biotin Azide Dadps;Biotin-PEG4-amino-t-Bu-DADPS-C6-azide;N-(2-((((6-Azidohexyl)oxy)diphenylsilyl)oxy)-2-methylpropyl)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide
CBNumber: CB78054673
Molecular Formula: C43H67N7O9SSi
Formula Weight: 886.19
MOL File: 1260247-50-4.mol

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Biotin-PEG4-amino-t-Bu-DADPS-C6-azide Property

storage temp.: Storage temp. -20°C
solubility: DMSO: 100 mg/mL (112.84 mM)
form: Solid
color: Off-white to light yellow
InChI: InChI=1/C43H67N7O9SSi/c1-43(2,59-61(35-15-7-5-8-16-35,36-17-9-6-10-18-36)58-24-14-4-3-13-22-47-50-44)34-46-40(52)21-25-54-27-29-56-31-32-57-30-28-55-26-23-45-39(51)20-12-11-19-38-41-37(33-60-38)48-42(53)49-41/h5-10,15-18,37-38,41H,3-4,11-14,19-34H2,1-2H3,(H,45,51)(H,46,52)(H2,48,49,53)/t37-,38-,41-/s3
InChIKey: CSHHHVOFXKFHMG-JUSAZYRUNA-N
SMILES: [Si](C1C=CC=CC=1)(C1C=CC=CC=1)(OCCCCCCN=[N+]=[N-])OC(C)(C)CNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@]2([H])NC(=O)N[C@]12[H] |&1:52,55,61,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Chem-Impex

Product number: 35159
Product name: DADPSbiotinazide
Packaging: 1MG
Price: $134.4
Updated: 2021/12/16

BroadPharm

Product number: BP-24315
Product name: DADPSBiotinAzide
Purity: 90%
Packaging: 5mg
Price: $239
Updated: 2021/12/16

Chem-Impex

Product number: 35159
Product name: DADPSbiotinazide
Packaging: 5MG
Price: $291.2
Updated: 2021/12/16

BroadPharm

Product number: BP-24315
Product name: DADPSBiotinAzide
Purity: 90%
Packaging: 25mg
Price: $679
Updated: 2021/12/16

Chem-Impex

Product number: 35159
Product name: DADPSbiotinazide
Packaging: 25MG
Price: $896.9
Updated: 2021/12/16

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Biotin-PEG4-amino-t-Bu-DADPS-C6-azide Chemical Properties,Usage,Production

Description

DADPS Biotin Azide probes eliminate a major limitation of the streptavidin-biotin affinity purification. This reagent contains a biotin moiety and an azide moiety. DADPS probe can be used in biomolecular labeling and proteomic studies. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Uses

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Biotin-PEG4-amino-t-Bu-DADPS-C6-azide Preparation Products And Raw materials

Raw materials

Preparation Products

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Biotin-PEG4-amino-t-Bu-DADPS-C6-azide Suppliers

China 29 United States 4 Global 33

Xi'an Confluore Biological Technology Co., Ltd.

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View Lastest Price from Biotin-PEG4-amino-t-Bu-DADPS-C6-azide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Biotin-Dadps-azide 1260247-50-4
Price: US $0.00/mg
Min. Order: 250mg
Purity: >95.00%
Supply Ability: 250mg
Release date: 2024-03-30

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DADPS Biotin Azide

DADPS Biotin Azide Dadps

N-(2-((((6-Azidohexyl)oxy)diphenylsilyl)oxy)-2-methylpropyl)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide

1260247-50-4