2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione
- Product Name
- 2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione
- CAS No.
- 1496997-41-1
- Chemical Name
- 2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione
- Synonyms
- Poma-5,6-2F;QLS12003-605-1;Thalidomide-5,6-F;6-difluoroisoindoline-1;6-Dioxopiperidin-3-yl)-5;5,6-Difluoro-thalidomide,AUN97411;2-(2,6-Dioxo-3-piperidyl)-5,6-difluoroisoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5,6-difluoro-
- CBNumber
- CB78056031
- Molecular Formula
- C13H8F2N2O4
- Formula Weight
- 294.21
- MOL File
- 1496997-41-1.mol
2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Property
- Boiling point:
- 534.6±50.0 °C(Predicted)
- Density
- 1.633±0.06 g/cm3(Predicted)
- form
- Solid
- pka
- 10.50±0.40(Predicted)
- color
- Off-white to gray
- InChI
- InChI=1S/C13H8F2N2O4/c14-7-3-5-6(4-8(7)15)13(21)17(12(5)20)9-1-2-10(18)16-11(9)19/h3-4,9H,1-2H2,(H,16,18,19)
- InChIKey
- AGHXYRKTAZEQQW-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(F)C(F)=C2)C(=O)N1C1CCC(=O)NC1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Chemical Properties,Usage,Production
Description
Thalidomide-5,6-F is used in the recruitment of the cereblon protein and also used as a PROTAC linker.
Uses
Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1].
IC 50
Cereblon
References
[1] Liu K, et al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013;11(29):4757-4763. DOI:10.1039/c3ob40595h
2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione manufacturers
- Product
- 2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione 1496997-41-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-18