2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Property

Boiling point:

534.6±50.0 °C(Predicted)

Density 

1.633±0.06 g/cm3(Predicted)

form 

Solid

pka

10.50±0.40(Predicted)

color 

Off-white to gray

InChI

InChI=1S/C13H8F2N2O4/c14-7-3-5-6(4-8(7)15)13(21)17(12(5)20)9-1-2-10(18)16-11(9)19/h3-4,9H,1-2H2,(H,16,18,19)

InChIKey

AGHXYRKTAZEQQW-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C=C(F)C(F)=C2)C(=O)N1C1CCC(=O)NC1=O

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione Chemical Properties,Usage,Production

Description

Thalidomide-5,6-F is used in the recruitment of the cereblon protein and also used as a PROTAC linker.