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DS-1971a

Product Name
DS-1971a
CAS No.
1450595-86-4
Chemical Name
DS-1971a
Synonyms
DS-1971a;DS-1971a, 10 mM in DMSO;Benzenesulfonamide, 5-chloro-2-fluoro-4-[[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy]-N-4-pyrimidinyl-;5-Chloro-2-fluoro-4-(((1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl)oxy)-N-(pyrimidin-4-yl)benzenesulfonamide;5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide;hypersensitivity,thermal,Sodium Channel,hyperalgesia,Na channels,inhibit,Na+ channels,Inhibitor,toxicity,DS 1971a,DS-1971a,DS1971a,mechanical
CBNumber
CB78065880
Molecular Formula
C20H21ClFN5O3S
Formula Weight
465.93
MOL File
1450595-86-4.mol
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DS-1971a Property

Boiling point:
638.8±65.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
solubility 
DMSO:100.0(Max Conc. mg/mL);214.63(Max Conc. mM)
pka
3.81±0.10(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0130195
Product name
DS-1971a
Purity
99.66%
Packaging
25mg
Price
$1050
Updated
2021/12/16
ChemScene
Product number
CS-0130195
Product name
DS-1971a
Purity
99.66%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0130195
Product name
DS-1971a
Purity
99.66%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0130195
Product name
DS-1971a
Purity
99.66%
Packaging
10mg
Price
$550
Updated
2021/12/16
DC Chemicals
Product number
020465
Product name
DS-1971a
Packaging
001
Price
$900
Updated
2021/12/16
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DS-1971a Chemical Properties,Usage,Production

Uses

DS-1971a is a potent, selective, and orally active NaV1.7 inhibitor, with IC50s of 22.8 and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects[1].

in vivo

DS-1971a exhibits a favorable toxicological profile[1].
DS-1971a (0.1-1 mg/kg; p.o.) shows mitigated thermal hyperalgesia in a dose-dependent manner in partial sciatic nerve ligation (PSL) mice[1].

Animal Model:Male Slc:ddY mice (PSL model)[1]
Dosage:0.1, 0.3, and 1 mg/kg
Administration:P.o.
Result:A significant dose-dependent suppression of thermal hyperalgesiain 0.3 and 1 mg/kg administered groups. The ED50 of DS-1971a at the peak efficacy was 0.32 mg/kg.

IC 50

hNav1.7: 22.8 nM (IC50); mNav1.7: 59.4 nM (IC50)

References

[1] Shinozuka T, et al. Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor [published online ahead of print, 2020 May 26]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00259. DOI:10.1021/acs.jmedchem.0c00259

DS-1971a Preparation Products And Raw materials

Raw materials

Preparation Products

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DS-1971a Suppliers

China 31 United States 3 Global 34
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9119
Advantage
58
Fujian boshi pharmaceutical technology co. LTD
Tel
0595-22008920; 18120708884
Email
393612455@qq.com
Country
China
ProdList
255
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9814
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58
Hubei wei shi reagent group ltd., company
Tel
027-59102966 18717199209
Fax
027-59379337
Email
2853877583@qq.com
Country
China
ProdList
2716
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58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62220
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58

1450595-86-4, DS-1971aRelated Search:


  • DS-1971a
  • Benzenesulfonamide, 5-chloro-2-fluoro-4-[[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy]-N-4-pyrimidinyl-
  • hypersensitivity,thermal,Sodium Channel,hyperalgesia,Na channels,inhibit,Na+ channels,Inhibitor,toxicity,DS 1971a,DS-1971a,DS1971a,mechanical
  • 5-Chloro-2-fluoro-4-(((1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl)oxy)-N-(pyrimidin-4-yl)benzenesulfonamide
  • 5-chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzene-1-sulfonamide
  • DS-1971a, 10 mM in DMSO
  • 1450595-86-4
  • C20H21ClFN5O3S