ChemicalBook > CAS DataBase List > iGOT1-01

iGOT1-01

Product Name
iGOT1-01
CAS No.
882256-55-5
Chemical Name
iGOT1-01
Synonyms
iGOT1-01;iGOT1-01, 10 mM in DMSO;1-Piperazinecarboxamide, 4-(1H-indol-4-yl)-N-phenyl-;4-?(1H-?Indol-?4-?yl)?-?N-?phenyl-1-?piperazinecarboxamid?e;iGOT1-01,GLOX,aspartate,Inhibitor,anti-cancer,transaminase,inhibit,iGOT1 01,GOT1,HRP,aminotransferase,glutamate,iGOT101,MDH,oxaloacetate
CBNumber
CB78066418
Molecular Formula
C19H20N4O
Formula Weight
320.39
MOL File
882256-55-5.mol
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iGOT1-01 Property

Boiling point:
620.8±55.0 °C(Predicted)
Density 
1.314±0.06 g/cm3(Predicted)
form 
Solid
pka
13.94±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom
Product number
AS713057
Product name
4-(1H-Indol-4-yl)-N-phenylpiperazine-1-carboxamide
Purity
98%
Packaging
5mg
Price
$59
Updated
2021/12/16
Arctom
Product number
AS713057
Product name
4-(1H-Indol-4-yl)-N-phenylpiperazine-1-carboxamide
Purity
98%
Packaging
10mg
Price
$99
Updated
2021/12/16
Arctom
Product number
AS713057
Product name
4-(1H-Indol-4-yl)-N-phenylpiperazine-1-carboxamide
Purity
98%
Packaging
25mg
Price
$168
Updated
2021/12/16
Arctom
Product number
AS713057
Product name
4-(1H-Indol-4-yl)-N-phenylpiperazine-1-carboxamide
Purity
98%
Packaging
50mg
Price
$287
Updated
2021/12/16
DC Chemicals
Product number
DC12541
Product name
iGOT1-01
Purity
>98%
Packaging
5mg
Price
$350
Updated
2021/12/16
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iGOT1-01 Chemical Properties,Usage,Production

Uses

iGOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor. iGOT1-01 has IC50s of 85 μM and 11.3 μM in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity[1][2].

in vivo

iGOT1-01 (compound 1a; 20 mg/kg; oral) has reasonable bioavailability and exposure properties (t1/2=0.7 hours, Cmax=4133 ng/mL, AUC(0-24 hours)=11734 hour?ng/mL)[1].

Animal Model:Female CD1 mice with 9 weeks old[1]
Dosage:20 mg/kg (Pharmacokinetic Analysis)
Administration:Oral
Result:Has reasonable bioavailability and exposure properties (t1/2=0.7 hours, Cmax=4133 ng/mL, AUC(0-24 hours)=11734 hour?ng/mL).

References

[1] Justin Anglin, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. DOI:10.1016/j.bmcl.2018.04.061
[2] Melissa C Holt, et al. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. 2018 Nov 27;57(47):6604-6614. DOI:10.1021/acs.biochem.8b00914

iGOT1-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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iGOT1-01 Suppliers

China 43 United States 3 Global 46
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1010
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
doncunbiosci@gmail.com
Country
China
ProdList
544
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58

882256-55-5, iGOT1-01Related Search:


  • iGOT1-01
  • 1-Piperazinecarboxamide, 4-(1H-indol-4-yl)-N-phenyl-
  • iGOT1-01,GLOX,aspartate,Inhibitor,anti-cancer,transaminase,inhibit,iGOT1 01,GOT1,HRP,aminotransferase,glutamate,iGOT101,MDH,oxaloacetate
  • iGOT1-01, 10 mM in DMSO
  • 4-?(1H-?Indol-?4-?yl)?-?N-?phenyl-1-?piperazinecarboxamid?e
  • 882256-55-5