MYF-01-37

Product Name: MYF-01-37
CAS No.: 2416417-65-5
Chemical Name: MYF-01-37
Synonyms: MYF-01-37;MYF-01-37 ，S8950;MYF-01-37, 10 mM in DMSO;1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one;1-(3-Methyl-3-((3-(trifluoromethyl)phenyl)amino)pyrrolidin-1-yl)prop-2-en-1-one;2-Propen-1-one, 1-[3-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1-pyrrolidinyl]-;Cys380,MYF 01 37,inhibit,Inhibitor,MYF0137,YAP/TEAD,Yes-associated protein,HEK293T,YAP
CBNumber: CB78066458
Molecular Formula: C15H17F3N2O
Formula Weight: 298.3
MOL File: 2416417-65-5.mol

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MYF-01-37 Property

Boiling point:: 421.7±45.0 °C(Predicted)
Density: 1.245±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (838.08 mM; Need ultrasonic)
pka: 5.17±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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MYF-01-37 Chemical Properties,Usage,Production

Uses

MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction[1].

IC 50

YAP/TAZ-TEAD

References

[1] Kari J Kurppa, et al. Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. Cancer Cell. 2020 Jan 13;37(1):104-122.e12. DOI:10.1016/j.ccell.2019.12.006

MYF-01-37 Preparation Products And Raw materials

Raw materials

Preparation Products

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MYF-01-37 Suppliers

China 46 United States 3 Global 49

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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2416417-65-5, MYF-01-37Related Search:

MYF-01-37

1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one

Cys380,MYF 01 37,inhibit,Inhibitor,MYF0137,YAP/TEAD,Yes-associated protein,HEK293T,YAP

2-Propen-1-one, 1-[3-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1-pyrrolidinyl]-

1-(3-Methyl-3-((3-(trifluoromethyl)phenyl)amino)pyrrolidin-1-yl)prop-2-en-1-one

MYF-01-37, 10 mM in DMSO

MYF-01-37 ，S8950

2416417-65-5