(S)-1-PYRIDIN-2-YL-ETHYLAMINE

Product Name: (S)-1-PYRIDIN-2-YL-ETHYLAMINE
CAS No.: 45695-03-2
Chemical Name: (S)-1-PYRIDIN-2-YL-ETHYLAMINE
Synonyms: (R)-1-(2-Pyridyl)ethylaMine;(S)-1-PYRIDIN-2-YL-ETHYLAMINE;2-[(1R)-1-Aminoethyl]pyridine;(R)-1-(pyridinyl-2yl)ethylamine;[(1R)-1-(2-pyridinyl)ethyl]amine;(+)-2-[(1R)-1-Aminoethyl]pyridine;(R)-1-(pyridin-2-yl)ethan-1-amine;(+)-2-[(1R)-1-Aminoethyl]pyridine;(1R)-(+)-1-(Pyridin-2-yl)ethylamine;(aR)-a-Methyl-2-PyridineMethanaMine
CBNumber: CB7812437
Molecular Formula: C7H10N2
Formula Weight: 122.17
MOL File: Mol file

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(S)-1-PYRIDIN-2-YL-ETHYLAMINE Property

Boiling point:: 194.5±15.0 °C(Predicted)
Density: 1.018±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.05±0.39(Predicted)
Appearance: Light yellow to yellow Liquid
optical activity: Consistent with structure
InChI: InChI=1/C7H10N2/c1-6(8)7-4-2-3-5-9-7/h2-6H,8H2,1H3/t6-/s3
InChIKey: PDNHLCRMUIGNBV-ISZMHOAENA-N
SMILES: N[C@H](C1=NC=CC=C1)C |&1:1,r|

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: OR70108
Product name: (+)-2-[(1R)-1-Aminoethyl]pyridine
Purity: 98%
Packaging: 1g
Price: $131
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-A9
Product name: (+)-2-[(1R)-1-Aminoethyl)]pyridine
Packaging: 1g
Price: $144
Updated: 2021/12/16

AK Scientific

Product number: W6374
Product name: (R)-1-Pyridin-2-yl-ethylamine
Packaging: 1g
Price: $176
Updated: 2021/12/16

Activate Scientific

Product number: AS24908
Product name: (R)-1-(2-Pyridyl)ethylamine
Purity: 97+% ee
Packaging: 1g
Price: $329
Updated: 2021/12/16

Apolloscientific

Product number: OR70108
Product name: (+)-2-[(1R)-1-Aminoethyl]pyridine
Purity: 98%
Packaging: 5g
Price: $520
Updated: 2021/12/16

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(S)-1-PYRIDIN-2-YL-ETHYLAMINE Chemical Properties,Usage,Production

Synthesis

216753-06-9

27854-90-6

(C) Asymmetric reduction reaction using a chiral spiroborate catalyst to convert O-benzyl pyridyl alkyl ketoxime 13 to the target product. This was carried out as follows: 2-, 3- or 4-pyridyl alkyl oxime ethers were prepared and reduced in the presence of catalyst 5, depending on the reaction conditions, as shown in Figure 6 and Table 8. In the case of 4-acetylpyridine O-benzyl oxime (13a), the reduction was carried out using 5 equivalents of BH3-THF in dioxane at 0 °C to give N-(1-pyridinyl-4-ethyl)-acetamide (14a), which achieved an enantiomeric excess (ee) value of 99%, but with a lower chemical yield, as shown in Table 8 entry 4. Despite stirring the reaction mixture in an ice bath for 4 days, TLC analysis still showed unreacted feedstock. Attempts to reduce 4-pyridyl oxime ether (entries 1-3) using THF and tert-butyl methyl ether as solvents revealed dioxane as the best solvent. To improve the conversion, the reduction was switched to THF at room temperature, and the reaction was completed after two days, but with a decrease in the ee value (entry 2). In addition, the reduction of 3-pyridyl oxime ether was studied at different temperatures and catalyst amounts. It was found that the reaction was completed after 48 hours of stirring at 10°C using a 30% catalyst loaded dioxane solution with an 84% yield of the isolated product and an ee value >98% (entry 8). A similar optimization study was conducted for the reduction of 13c and found that moderate yields and ee values of 60% were obtained in the presence of 1.0 equiv. of catalyst and 2.0 equiv. of borane (entry 10). Attempts to use 0.3 equivalents of catalyst 5 in dioxane at 10 °C and to protect the pyridine nitrogen with BEt3 (entry 11) were unsatisfactory. The addition of BF3 increased the yield but decreased the enantioselectivity (entry 12). For the reduction of 2-pyridyl oxime benzyl ether, a chemically calculated amount of catalyst 5 was required to complete the reaction, but the ee value was moderate (entry 10). The reaction products listed in Table 8 were separated by column chromatography and the ee values were determined by GC analysis of the acetyl derivatives (using a chiral column CP-Chirasil-DexCB).

References

[1] Patent: WO2008/27740, 2008, A2. Location in patent: Page/Page column 14-15

(S)-1-PYRIDIN-2-YL-ETHYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-PYRIDIN-2-YL-ETHYLAMINE Suppliers

China 97 India 1 United Kingdom 1 United States 8 Global 107

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View Lastest Price from (S)-1-PYRIDIN-2-YL-ETHYLAMINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-1-PYRIDIN-2-YL-ETHYLAMINE 45695-03-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Career Henan Chemical Co

Product: (1R)-(+)-1-(Pyridin-2-yl)ethylamine 45695-03-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2019-08-05

45695-03-2, (S)-1-PYRIDIN-2-YL-ETHYLAMINERelated Search:

1-PYRIDIN-2-YL-ETHYLAMINE

(S)-1-PYRIDIN-2-YL-ETHYLAMINE

(R)-1-(2-Pyridyl)ethylaMine

2-PyridineMethanaMine, a-Methyl-, (R)-

(+)-2-[(1R)-1-Aminoethyl]pyridine

(1R)-(+)-1-(Pyridin-2-yl)ethylamine

2-Pyridinemethanamine, α-methyl-, (αR)-

(R)-1-(pyridinyl-2yl)ethylamine

[(1R)-1-(2-pyridinyl)ethyl]amine

2-PyridineMethanaMine, a-Methyl-, (aR)-

(aR)-a-Methyl-2-PyridineMethanaMine

(+)-2-[(1R)-1-Aminoethyl]pyridine 98%

(S)-1-PYRIDIN-2-YL-ETHYLAMINE ISO 9001：2015 REACH

(R)-1-(pyridin-2-yl)ethan-1-amine

(αR)-α-Methyl-2-pyridinemethanamine

(+)-2-[(1R)-1-Aminoethyl]pyridine

2-[(1R)-1-Aminoethyl]pyridine

45695-03-2

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