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Ensifentrine

Product Name: Ensifentrine
CAS No.: 1884461-72-6
Chemical Name: Ensifentrine
Synonyms: Ensifentrine;(E)-RPL-554;Ensifentrina;Ensifentrinum;Ensifentrine ( RPL554 );Ensifentrine, 10 mM in DMSO;EnsifentrineQ: What is Ensifentrine Q: What is the CAS Number of Ensifentrine;(E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea;N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]-;(E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea , Ensifentrine
CBNumber: CB78138104
Molecular Formula: C26H31N5O4
Formula Weight: 477.56
MOL File: 1884461-72-6.mol

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Ensifentrine Property

Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (52.35 mM; Need ultrasonic)
form: Solid
pka: 13.73±0.46(Predicted)
color: Light yellow to green yellow
InChIKey: CSOBIBXVIYAXFM-BYNJWEBRSA-N
SMILES: N(CCN1/C(=N/C2=C(C)C=C(C)C=C2C)/C=C2C3=C(C=C(OC)C(OC)=C3)CCN2C1=O)C(N)=O

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Hazard and Precautionary Statements (GHS)

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Ensifentrine Chemical Properties,Usage,Production

Uses

RPL 554 is a known drug candidate for respiratory diseases, particularly in patients with asthma or chronic obstructive pulmonary diseases.

in vivo

Ensifentrine (RPL-554; 10 mg/kg; Oral administration; once) significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs^[1].
The inhalation of dry powder containing Ensifentrine by conscious guinea pigs (25% in micronized lactose) 1.5 h before antigen exposure significantly inhibits the recruitment of eosinophils to the airways^[1].
Exposure of conscious guinea pigs to inhalation of dry powder containing Ensifentrine (2.5%) in micronized lactose significantly inhibits histamine-induced plasma protein extravasation in the trachea and histamine-induced bronchoconstriction over a 5.5-h period^[1].

Animal Model:	Male Dunkin Hartley guinea pigs (200-300 g) injected with ovalbumin^[1].
Dosage:	10 mg/kg
Administration:	Oral administration; once
Result:	Significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs.

IC 50

PDE3: 0.4 nM (IC₅₀); PDE4: 1479 nM (IC₅₀)

Ensifentrine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ensifentrine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ensifentrine 1884461-72-6
Price: US $2.20-8.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons
Release date: 2025-07-08

Wuhan JiyunZen Tech Co., Ltd.

Product: Ensifentrine 1884461-72-6
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-06-05

1884461-72-6, EnsifentrineRelated Search:

2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-(3,4-dimethoxyphenyl)- N-Nitroso Ensifentrine-d6 N-Nitroso Ensifentrine

Urea, N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]-

Ensifentrine

Ensifentrine ( RPL554 )

EnsifentrineQ: What is Ensifentrine Q: What is the CAS Number of Ensifentrine

Ensifentrina

Ensifentrinum

RPL 554,RPL554,inhaled,Inhibitor,RPL-554,Ensifentrine,bronchoprotective,inhibit,COPD,PDE4,anti-inflammatory,PDE3,Phosphodiesterase (PDE)

Ensifentrine, 10 mM in DMSO

(E)-RPL-554

(E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea

(E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea , Ensifentrine

N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]-

1884461-72-6

188461-72-6

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