AKOS BRN-1022
- Product Name
- AKOS BRN-1022
- CAS No.
- 900174-62-1
- Chemical Name
- AKOS BRN-1022
- Synonyms
- AKOS BRN-1022;(4-Chloro-3-ethoxyphenyl);(4-CHLORO-3-ETHOXYPHENYL)BORONIC ACID;Boronic acid, B-(4-chloro-3-ethoxyphenyl)-
- CBNumber
- CB7820153
- Molecular Formula
- C8H10BClO3
- Formula Weight
- 200.43
- MOL File
- 900174-62-1.mol
AKOS BRN-1022 Property
- Boiling point:
- 351.3±52.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- pka
- 7.96±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C370958
- Product name
- 4-Chloro-3-ethoxyphenylboronicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C370958
- Product name
- 4-Chloro-3-ethoxyphenylboronicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC160894
- Product name
- 4-Chloro-3-ethoxyphenylboronic acid
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Z1050
- Product name
- 4-Chloro-3-ethoxyphenylboronicacid
- Packaging
- 1g
- Price
- $91
- Updated
- 2021/12/16
- Product number
- FC160894
- Product name
- 4-Chloro-3-ethoxyphenylboronic acid
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
AKOS BRN-1022 Chemical Properties,Usage,Production
Uses
4-Chloro-3-ethoxyphenylboronic acid
Synthesis
900174-61-0
900174-62-1
The general procedure for the synthesis of 4-chloro-3-ethoxyphenylboronic acid from 4-bromo-1-chloro-2-ethoxybenzene was as follows: n-butyllithium (n-BuLi, 1.6 M hexanes solution, 13.6 mL, 21.8 mmol) was slowly added to a solution of tetrahydrofuran (THF, 20 mL) of Intermediate 15A (3.8 g, 16 mmol) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 40 min, followed by the addition of triisopropyl borate (7.43 mL, 32 mmol). The reaction system was slowly warmed from -78 °C to room temperature and stirring was continued for 18 hours. Upon completion of the reaction, the reaction was quenched with 1.0 N hydrochloric acid (50 mL) followed by extraction of the organic phase with ethyl acetate (EtOAc). The organic phase was washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). The crude product was purified by fast column chromatography (eluent ratio of dichloromethane: ethyl acetate: methanol = 50:50:1) to give 1.85 g (57% yield) of Intermediate 15B as a white solid. Its 1H NMR (400 MHz, CDCl3) data were as follows: δ 1.53 (t, J=7.03Hz, 3H), 4.23 (d, J=7.03Hz, 2H), 7.48 (d, J=7.91Hz, 1H), 7.66 (d, J=6.15Hz, 2H).
References
[1] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 43-44
AKOS BRN-1022 Preparation Products And Raw materials
Raw materials
Preparation Products
AKOS BRN-1022 Suppliers
- Tel
- --
- Fax
- --
- akos@akosgmbh.de
- Country
- Germany
- ProdList
- 6717
- Advantage
- 72
View Lastest Price from AKOS BRN-1022 manufacturers
- Product
- 4-CHLORO-3-ETHOXYPHENYL)BORONIC ACID 900174-62-1
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2020-01-08