Osimertinib Impurity 28

Product Name: Osimertinib Impurity 28
CAS No.: 1638281-44-3
Chemical Name: Osimertinib Impurity 28
Synonyms: D6-Osimertinib;2H6]-Osimertinib;Osimertinib Impurity 28;N-[2-({2-[di(2H?)methylamino]ethyl}(methyl)amino)-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl]prop-2-enamide
CBNumber: CB78232303
Molecular Formula: C28H33N7O2
Formula Weight: 499.62
MOL File: 1638281-44-3.mol

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Osimertinib Impurity 28 Property

form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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Osimertinib Impurity 28 Chemical Properties,Usage,Production

Uses

Osimertinib-d6 is a deuterium labeled osimertinib. Osimertinib is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer[1].

in vivo

Osimertinib (0.1-25 mg/kg; p.o.; daily for 14 day) induces significant dose-dependent regression in both PC-9 (ex19del) and H1975 (L858R/T790M) tumor xenograft models^[1].

Animal Model:	PC-9 (ex19del) and H1975 (L858R/T790M) tumor xenograft models^[1]
Dosage:	0.1-10 mg/kg (PC-9 xenograft models); 0.5- 25 mg/kg (H1975 xenograft models)
Administration:	p.o.; daily for 14 day
Result:	Induced significant dose-dependent regression in both PC-9 (ex19del) and H1975 (L858R/T790M) tumor xenograft models.

References

[1] Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61. DOI:10.1158/2159-8290.CD-14-0337
[2] [2]Hirano T, et al. Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, in EGFR-Mutated Non-Small Cell Lung Cancer. Mol Cancer Ther. 2018 Apr;17(4):740-750. DOI:10.1158/1535-7163.MCT-17-1033

Osimertinib Impurity 28 Preparation Products And Raw materials

Raw materials

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Osimertinib Impurity 28 Suppliers

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1638281-44-3, Osimertinib Impurity 28Related Search:

1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- Osimertinib mesylate Osimertinib-13CD3 1,2,4-Benzenetriamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]- Osimertinib Impurity M N-(2-(dimethylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide 4-fluoro-2-methoxy-3-nitrobenzenamine AZ 7550 1,4-Benzenediamine, 5-methoxy-N1,N1-dimethyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-2-nitro-

Osimertinib Impurity 28

2H6]-Osimertinib

N-[2-({2-[di(2H?)methylamino]ethyl}(methyl)amino)-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl]prop-2-enamide

D6-Osimertinib

1638281-44-3