5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-

Product Name: 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-
CAS No.: 2369979-67-7
Chemical Name: 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-
Synonyms: JHU37152, 10 mM in DMSO;8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine;8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-5H-Dibenzo[b,e][1,4]diazepine;5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-;JHU37152,inhibit,hM3Dq,Clozapine,Inhibitor,DREADD,Muscarinic acetylcholine receptor,mAChR,hM4Di,JHU-37152
CBNumber: CB78236806
Molecular Formula: C19H20ClFN4
Formula Weight: 358.84
MOL File: 2369979-67-7.mol

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5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Property

Boiling point:: 492.6±55.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO|35.88|100|ethanol|35.88|100|
form: solid
pka: 7.63±0.10(Predicted)
color: Yellow

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Hazard and Precautionary Statements (GHS)

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5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Chemical Properties,Usage,Production

Uses

JHU37152 is a potent and brain-penetrant DREADD agonist, with EC50s of 5?nM and 0.5?nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37152 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue[1].

in vivo

JHU37152 (0.1 mg/kg; i.p.) exhibits high DREADD occupancy in mice and rats^[1].
JHU37152 (0.01-1 mg/kg; i.p.) selectively inhibits locomotor activity in D1-hM3Dq and D1-hM4Di mice without any significant locomotor effects observed in WT mice^[1].

IC 50

mAChR3; mAChR4

storage

Room temperature

References

[1] Bonaventura J, et, al. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019 Oct 11;10(1):4627. DOI:10.1038/s41467-019-12236-z

5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Preparation Products And Raw materials

Raw materials

Preparation Products

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5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Suppliers

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2369979-67-7, 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-Related Search:

5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro-

5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-

8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-5H-Dibenzo[b,e][1,4]diazepine

JHU37152,inhibit,hM3Dq,Clozapine,Inhibitor,DREADD,Muscarinic acetylcholine receptor,mAChR,hM4Di,JHU-37152

JHU37152, 10 mM in DMSO

8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine

2369979-67-7

C19H20ClFN4