ChemicalBook > CAS DataBase List > Dot1L-IN-4

Dot1L-IN-4

Product Name
Dot1L-IN-4
CAS No.
2565705-02-2
Chemical Name
Dot1L-IN-4
Synonyms
Dot1L- IN-4;QQN05022(Dot1L-IN-4);H3K79,Histone Methyltransferase,histone,methyltransferase,lysine,DOT1L,Dot1L IN 4,Inhibitor,Dot-1L-IN-4,Dot1LIN4,inhibit;N1-[(3-Chloro-pyridin-2-yl)-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-methyl]-4-methanesulfonyl-N2-(4-methoxy-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-benzene-1,2-diamine;1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)-;N1-[(S)-(3-chloropyridin-2-yl)(2,2-difluoro-2H-1,3-benzodioxol-4-yl)methyl]-4-methanesulfonyl-N2-[4-methoxy-6-(piperazin-1-yl)-1,3,5-triazin-2-yl]benzene-1,2-diamine
CBNumber
CB78364259
Molecular Formula
C28H27ClF2N8O5S
Formula Weight
661.08
MOL File
2565705-02-2.mol
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Dot1L-IN-4 Property

Boiling point:
792.1±70.0 °C(Predicted)
Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (378.17 mM; Need ultrasonic)
form 
A solid
pka
8.67±0.10(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0109501
Product name
Dot1L-IN-4
Purity
99.60%
Packaging
5mg
Price
$580
Updated
2021/12/16
ChemScene
Product number
CS-0109501
Product name
Dot1L-IN-4
Purity
99.60%
Packaging
10mg
Price
$980
Updated
2021/12/16
ChemScene
Product number
CS-0109501
Product name
Dot1L-IN-4
Purity
99.60%
Packaging
25mg
Price
$1900
Updated
2021/12/16
ChemScene
Product number
CS-0109501
Product name
Dot1L-IN-4
Purity
99.60%
Packaging
50mg
Price
$3200
Updated
2021/12/16
ChemScene
Product number
CS-0109501
Product name
Dot1L-IN-4
Purity
99.60%
Packaging
100mg
Price
$5000
Updated
2021/12/16
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Dot1L-IN-4 Chemical Properties,Usage,Production

Biological Activity

Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM[1]. Dot1L-IN-4 (Compound 10) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=1.7 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=33 nM). Dot1L-IN-4 also inhibits mixed lineage leukemia (MLL) with an IC50 of 99 μM[1]. Dot1L-IN-4 (Compound 10; 300 mg/kg; p.o.; qd) is not tolerated at such a high dose by tumor xenograft bearing mice, and at a 6-fold reduced dose, the tumor growth as well as the HOXA9 reporter gene mRNA are reduced only by less than half as compared to control animals[1].

References

[1]. Frédéric Stauffer, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med. Chem. Lett. 2019, 10, 12, 1655-1660.

Dot1L-IN-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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Dot1L-IN-4 Suppliers

China 17 United States 4 Global 21
Wuhan Acumen Bio-Technology Co.,ltd
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027-027-16602739303 16602739303
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673003916@qq.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghai JingRon Chemical Technology Co., Ltd.
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021-60546673 13701861782
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QQ:670259431
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kuanga111@sina.com
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China
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ShangHai Biochempartner Co.,Ltd
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17754423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Rechem science Co., Ltd.
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21-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Shanghai SuperLan Chemcial Technique Centre
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021-2022843681 15618226720
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+86-21-51601218
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lucy@atkchemical.com
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China
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Heze Development Zone chuangli Chemical Co., Ltd.
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+86-530-529 6766，+86-15666160102 15666160102
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0530-529 6766
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info@chuangli-chem.com
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China
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DC Chemicals
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021-58447131 13564518121
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sales@dcchemicals.com
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China
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Changzhou Chenhong Biotechnology Co., Ltd.
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0519-85788828 13775037613
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sales@chemrenpharm.com
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China
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Chunchuang (Wuhan) Technology Co., Ltd
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15342225168
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yutianchun2007@126.com
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China
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InvivoChem
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13549236410
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sales@invivochem.cn
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China
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Wuhan Shanhai Zhihe Biotechnology Co., Ltd.
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shoubull@126.com
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https://hanhongsci.com/
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
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RD International Technology Co., Limited
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18024082417
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ATK CHEMICAL COMPANY LIMITED
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+undefined-21-51877795
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+86 21 5161 9052/ 5187 7796
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ivan@atkchemical.com
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China
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32956
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2565705-02-2, Dot1L-IN-4Related Search:


  • 1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)-
  • Dot1L- IN-4
  • QQN05022(Dot1L-IN-4)
  • N1-[(3-Chloro-pyridin-2-yl)-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-methyl]-4-methanesulfonyl-N2-(4-methoxy-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-benzene-1,2-diamine
  • H3K79,Histone Methyltransferase,histone,methyltransferase,lysine,DOT1L,Dot1L IN 4,Inhibitor,Dot-1L-IN-4,Dot1LIN4,inhibit
  • N1-[(S)-(3-chloropyridin-2-yl)(2,2-difluoro-2H-1,3-benzodioxol-4-yl)methyl]-4-methanesulfonyl-N2-[4-methoxy-6-(piperazin-1-yl)-1,3,5-triazin-2-yl]benzene-1,2-diamine
  • 2565705-02-2
  • C28H27ClF2N8O5S