6-HYDROXYNICOTINIC ACID ETHYL ESTER
- Product Name
- 6-HYDROXYNICOTINIC ACID ETHYL ESTER
- CAS No.
- 18617-50-0
- Chemical Name
- 6-HYDROXYNICOTINIC ACID ETHYL ESTER
- Synonyms
- NSC 165497;Ethyl 6-Hydroxynicotinate;Ethyl 6-Hydroxynicotinic acid ester;6-HYDROXYNICOTINIC ACID ETHYL ESTER;ethyl 6-oxo-1H-pyridine-3-carboxylate;Ethyl 6-hydroxypyridine-3-carboxylate;ethyl 6-oxo-1,6-dihydropyridine-3-carboxylate;6-Oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester;1,6-Dihydro-6-oxo-pyridin-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-, ethyl ester
- CBNumber
- CB7840856
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 18617-50-0.mol
6-HYDROXYNICOTINIC ACID ETHYL ESTER Property
- Melting point:
- 150 °C
- Boiling point:
- 347.5±42.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 10.10±0.10(Predicted)
- Appearance
- Light brown to gray Solid
- InChI
- InChI=1S/C8H9NO3/c1-2-12-8(11)6-3-4-7(10)9-5-6/h3-5H,2H2,1H3,(H,9,10)
- InChIKey
- YYNSXKLGLKOLQZ-UHFFFAOYSA-N
- SMILES
- C1NC(=O)C=CC=1C(OCC)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E939785
- Product name
- Ethyl6-Hydroxynicotinate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H58-1-HM
- Product name
- Ethyl 6-hydroxynicotinate
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 072753
- Product name
- 6-Hydroxynicotinic acid ethyl ester
- Purity
- 95+%
- Packaging
- 5g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- 072753
- Product name
- 6-Hydroxynicotinic acid ethyl ester
- Purity
- 95+%
- Packaging
- 10g
- Price
- $714
- Updated
- 2021/12/16
- Product number
- CHM0167229
- Product name
- 6-HYDROXYNICOTINIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $780.78
- Updated
- 2021/12/16
6-HYDROXYNICOTINIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis Reference(s)
Synthesis, p. 286, 1974 DOI: 10.1055/s-1974-23295
Synthesis
5006-66-6
64-17-5
18617-50-0
Preparation of ethyl 6-hydroxynicotinate: to a solution of 6-hydroxynicotinate (5.0 g, 35.9 mmol) in anhydrous ethanol (180 mL) was slowly added concentrated sulfuric acid (1.0 mL). The reaction mixture was stirred at 60 °C for 20 min, followed by the addition of additional ethanol (33.0 mL), and the reaction system was heated to reflux with continuous stirring for 6.5 h. The reaction mixture was then stirred for 6.5 h at 60 °C for 1.5 min. Upon completion of the reaction, the reaction solution was cooled to 0 °C and saturated aqueous sodium bicarbonate solution was slowly added to neutralize the reaction solution. Subsequently, the ethanol was removed by concentration under reduced pressure by rotary evaporator. The aqueous phase was extracted with ethyl acetate and the organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give the white crystalline product ethyl 6-hydroxynicotinate (5.33 g, 89% yield). The product was characterized by 1H-NMR (CDCl3): δ 1.36 (3H, t, J = 7.1 Hz), 4.33 (2H, q, J = 7.1 Hz), 6.58 (1H, d, J = 9.5 Hz), 8.01 (1H, dd, J = 2.4, 9.5 Hz), 8.19 (1H, d, J = 2.4 Hz), 12.43 (1H brs).
References
[1] Patent: US2010/48610, 2010, A1. Location in patent: Page/Page column 83
[2] Journal of Fluorine Chemistry, 2017, vol. 203, p. 155 - 165
[3] Patent: EP1900735, 2008, A1. Location in patent: Page/Page column 14-15
[4] Journal of the Chemical Society, 1908, vol. 93, p. 1379
6-HYDROXYNICOTINIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-HYDROXYNICOTINIC ACID ETHYL ESTER manufacturers
- Product
- 6-HYDROXYNICOTINIC ACID ETHYL ESTER 18617-50-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09