3,5-DIFLUORO-4-HYDROXY-BENZONITRILE

Product Name: 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE
CAS No.: 2967-54-6
Chemical Name: 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE
Synonyms: 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE;Benzonitrile, 3,5-difluoro-4-hydroxy-;3,5-Difluoro-4-hydroxybenzonitrile,97%
CBNumber: CB7843741
Molecular Formula: C7H3F2NO
Formula Weight: 155.1
MOL File: 2967-54-6.mol

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3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Property

Melting point:: 200-208℃
Boiling point:: 221.0±40.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 5.34±0.23(Predicted)
Appearance: White to off-white Solid

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Safety

HazardClass: 6.1
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D447443
Product name: 3,5-Difluoro-4-hydroxybenzonitrile
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: D447443
Product name: 3,5-Difluoro-4-hydroxybenzonitrile
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD104629
Product name: 3,5-difluoro-4-hydroxybenzonitrile
Packaging: 1g
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: Z4572
Product name: 3,5-Difluoro-4-hydroxybenzonitrile
Packaging: 1g
Price: $61
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD104629
Product name: 3,5-difluoro-4-hydroxybenzonitrile
Packaging: 2g
Price: $90
Updated: 2021/12/16

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3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Chemical Properties,Usage,Production

Uses

3,5-Difluoro-4-hydroxybenzonitrile

Synthesis

960287-97-2

2967-54-6

The general procedure for the synthesis of 3,5-difluoro-4-hydroxybenzonitrile from 3,5-difluoro-4-hydroxybenzaldehyde oxime is as follows: to a solution of tetrahydrofuran (THF, 10 mL) containing the aldoxime (0.01 mol) was added T3P (15 mol%, 50% solution in ethyl acetate (EtOAc)). The reaction mixture was stirred at room temperature for 1-2 h under nitrogen protection. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the solvent was removed under reduced pressure. The residue was diluted with distilled water (20 mL) and subsequently extracted with ethyl acetate (2 x 20 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate (NaHCO3) solution (10 mL) and brine. The organic phase was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford the target product 3,5-difluoro-4-hydroxybenzonitrile of high purity.

References

[1] Tetrahedron Letters, 2011, vol. 52, # 10, p. 1074 - 1077

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-DIFLUORO-4-HYDROXY-BENZONITRILE Suppliers

China 63 India 2 Switzerland 1 United Kingdom 2 United States 10 Global 78

Alfa Aesar

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SynAsst Chemical.

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View Lastest Price from 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE manufacturers

Career Henan Chemical Co

Product: 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE 2967-54-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-25

2967-54-6, 3,5-DIFLUORO-4-HYDROXY-BENZONITRILERelated Search:

BISMERTHIAZOL 4-METHOXY-2,3,5-TRIFLUOROBENZONITRILE 3-Fluoro-4-hydroxybenzonitrile 3,5-DIFLUORO-4-METHOXYBENZONITRILE 3,5-DIFLUORO-4-HYDROXY-BENZONITRILE

3,5-DIFLUORO-4-HYDROXY-BENZONITRILE

Benzonitrile, 3,5-difluoro-4-hydroxy-

3,5-Difluoro-4-hydroxybenzonitrile,97%

2967-54-6