2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE

Product Name: 2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE
CAS No.: 25710-18-3
Chemical Name: 2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE
Synonyms: 2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE;Pyrido[2,3-b]pyrazine, 2,3-dichloro-;2,3-dichloropyridine [2,3-b] pyrazine
CBNumber: CB7849637
Molecular Formula: C7H3Cl2N3
Formula Weight: 200.02
MOL File: 25710-18-3.mol

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2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE Property

Melting point:: 144-146 °C
Boiling point:: 282.3±35.0 °C(Predicted)
Density: 1.573±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.19±0.30(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C7H3Cl2N3/c8-5-6(9)12-7-4(11-5)2-1-3-10-7/h1-3H
InChIKey: HWJDFFLZOOKZNL-UHFFFAOYSA-N
SMILES: C12=NC=CC=C1N=C(Cl)C(Cl)=N2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D482543
Product name: 2,3-dichloropyrido[2,3-b]pyrazine
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139666
Product name: 2,3-Dichloropyrido[2,3-b]pyrazine
Packaging: 100mg
Price: $123
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139666
Product name: 2,3-Dichloropyrido[2,3-b]pyrazine
Packaging: 250mg
Price: $237.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139666
Product name: 2,3-Dichloropyrido[2,3-b]pyrazine
Packaging: 500mg
Price: $365
Updated: 2021/12/16

AK Scientific

Product number: 2128AB
Product name: 2,3-Dichloropyrido[2,3-b]pyrazine
Packaging: 250mg
Price: $153
Updated: 2021/12/16

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2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE Chemical Properties,Usage,Production

Synthesis

2067-84-7

25710-18-3

General procedure for the synthesis of 2,3-dichloro-pyrido[2,3-B]pyrazine-2,3(1H,4H)-dione from pyrido[2,3-B]pyrazine: 5 g (30.7 mmol) of pyrido[2,3-B]pyrazine-2,3(1H,4H)-dione was dissolved in 50 mL of phosphorus oxychloride (POCl3). The reaction mixture was heated to reflux for 24 hours. Upon completion of the reaction, the reaction solution was concentrated under vacuum to completely remove POCl3. The concentrated residue was carefully poured into ice water and extracted with ethyl acetate (EtOAc). The organic phases were combined, washed sequentially with saturated NaHCO3 solution and brine, and dried over anhydrous sodium sulfate. The dried organic phases were concentrated under reduced pressure to give a white powder of 2,3-dichloropyrido[3,2-b]pyrazine in 81% yield.

References

[1] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 7, p. 1778 - 1783
[2] Journal of Chemical Ecology, 1996, vol. 22, # 5, p. 1051 - 1074
[3] Journal of Organic Chemistry, 2005, vol. 70, # 7, p. 2878 - 2880
[4] Patent: WO2007/23186, 2007, A1. Location in patent: Page/Page column 67
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 2949 - 2961

2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE Suppliers

China 51 India 1 United Kingdom 2 United States 6 Global 60

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25710-18-3, 2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINERelated Search:

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2,3-DICHLORO-PYRIDO[2,3-B]PYRAZINE

Pyrido[2,3-b]pyrazine, 2,3-dichloro-

2,3-dichloropyridine [2,3-b] pyrazine

25710-18-3