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Mofezolac

Product Name
Mofezolac
CAS No.
78967-07-4
Chemical Name
Mofezolac
Synonyms
N-22;Disopain;Mofezolac;3,4-Bis(4-methoxyphenyl)isoxazole-5-acetic acid;3,4-Bis(4-methoxyphenyl)-5-isoxazoleacetic acid;5-Isoxazoleacetic acid, 3,4-bis(4-methoxyphenyl)-;2-(3,4-bis(4-Methoxyphenyl)isoxazol-5-yl)acetic acid;α-[3,4-Bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid;2-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid;Mofezolac,inhibit,platelet,COX,Inhibitor,aggregation,NSAID,Cyclooxygenase,pain,anti-inflammatory,COX-1,analgesic
CBNumber
CB7875698
Molecular Formula
C19H17NO5
Formula Weight
339.34
MOL File
78967-07-4.mol
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Mofezolac Property

Melting point:
147.5℃
Boiling point:
527.2±50.0 °C(Predicted)
Density 
1.250±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
A solid
pka
pKa ~3.3(at 25℃)
color 
White to off-white
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Safety

Toxicity
LD50 in male, female mice, male, female rats (mg/kg): 1528, 1740, 920, 887 orally; 275, 321, 378, 342 i.p.; 612, 545, 572, 510 s.c. (Satoh)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R678899
Product name
(3,4-BIS(4-METHOXYPHENYL)-5-ISOXAZOLYL)ACETIC ACID
Purity
AldrichCPR
Packaging
25MG
Price
$179
Updated
2024/03/01
Matrix Scientific
Product number
007780
Product name
[3,4-Bis-(4-methoxyphenyl)isoxazol-5-yl]-acetic acid
Packaging
1g
Price
$378
Updated
2021/12/16
AK Scientific
Product number
9783AE
Product name
[3,4-Bis-(4-methoxyphenyl)isoxazol-5-yl]-aceticacid
Packaging
25mg
Price
$496
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015838
Product name
[3,4-BIS-(4-METHOXY-PHENYL)ISOXAZOL-5-YL]ACETIC ACID
Purity
95.00%
Packaging
1G
Price
$778
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573140
Product name
Mofezolac
Purity
>98%
Packaging
100mg
Price
$1060.8
Updated
2021/12/16
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Mofezolac Chemical Properties,Usage,Production

Description

Mofezolac is a new non-steroidal analgesic antiinflammatory agent introduced in Japan for the treatment of post-operative and post-traumatic pain, acute upper respiratory tract pain, osteoarthritis, and lumbago. In in vfim studies, mofezolac inhibits prostaglandin biosynthesis and platelet aggregation, reportedly through the inhibition of cyclooxygenase. In animal studies, mofezolac showed more potent suppression in various writhing models than agents such as ibuprofen, mefenamic acid and aspirin. Mofezolac also has a potent inhibitory activity on the algesic responses induced by the mechanical stimulus of the inflamed tissue. The ulcerogenic effect of mofezolac on the gastric mucosa is far weaker than that of indomethacin and other agents.

Originator

Pasteur Merieux (France)

Definition

ChEBI: Mofezolac (TN) is a member of methoxybenzenes.

brand name

Disopain

Clinical Use

Yoshitomi (now Mitsubishi Pharma) has launched mofezolac, a COX-1 inhibitor with preferential COX-1 inhibition for the treatment of arthritis-related pain in Japan. The compound is used in oral doses of 75mg for the treatment of periarthritis, lumbago, neckshoulder- arm syndrome and pain after surgery, trauma, or dental extraction.

Synthesis

The reaction of deoxyanisoin with hydroxylamine in methanol gives the corresponding 1,2-bis(4-methoxyphenyl)ethanone oxime, which is cyclized with ethyl acetate by means of n-butyllithium in tetrahydrofuran yielding 3,4-di(4-methoxyphenyl)-5-methylisoxazole. Finally, this compound is condensed with CO2 with n-butyllithium as catalyst in tetrahydrofuran to yield mofezolac . The synthesis with ClCO2C2H5 instead of CO2 is described in .

Mofezolac Preparation Products And Raw materials

Raw materials

Preparation Products

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Mofezolac Suppliers

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78967-07-4, MofezolacRelated Search:

3-METHYL-5-ISOXAZOLEACETIC ACID 98 Mofezolac AKOS 90454 4-PHENYLISOXAZOLE 3-(4-METHOXYPHENYL)ISOXAZOLE

  • Mofezolac
  • 3,4-Bis(4-methoxyphenyl)isoxazole-5-acetic acid
  • Disopain
  • N-22
  • α-[3,4-Bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid
  • 2-(3,4-bis(4-Methoxyphenyl)isoxazol-5-yl)acetic acid
  • 3,4-Bis(4-methoxyphenyl)-5-isoxazoleacetic acid
  • 5-Isoxazoleacetic acid, 3,4-bis(4-methoxyphenyl)-
  • Mofezolac,inhibit,platelet,COX,Inhibitor,aggregation,NSAID,Cyclooxygenase,pain,anti-inflammatory,COX-1,analgesic
  • 2-[3,4-bis(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid
  • 78967-07-4