[R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride

Product Name: [R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride
CAS No.: 16777-42-7
Chemical Name: [R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride
Synonyms: D 563;Modacor;Ildamen;FDA 1576;OXYFEDRINE HCL;L-OXYFEDRINE HCL;Ildamen USP/EP/BP;L-Form hydrochloride;Oxyfedrine L-form HCl;OXYFEDRINEHYROCHLORIDE
CBNumber: CB7882175
Molecular Formula: C19H23NO3.ClH
Formula Weight: 349.85
MOL File: 16777-42-7.mol

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[R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Property

Melting point:: 192-194℃
form: Solid
color: White to off-white

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Safety

Toxicity: LD50 in mice (mg/kg): 29 i.v. (Hueller)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0005074
Product name: OXYFEDRINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $502.96
Updated: 2021/12/16

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[R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Chemical Properties,Usage,Production

Originator

Ildamen,Homburg,W. Germany ,1966

Uses

Oxyfedrine hydrochloride, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine hydrochloride can be used in the research of cardiovascular disease[1][2].

Manufacturing Process

45 grams of m-methoxy acetophenone, 8 grams of paraformaldehyde and 30.2 grams of 1 norephedrine were mixed with about 135 cc of isopropanol HCl solution to provide a pH of 4 and the mixture refluxed for 4 hours. The reaction mixture was cooled and the crystals filtered off on a suction filter. 3[1-phenyl-1-hydroxypropyl-(2)-amino]-1-(m-methoxyphenyl)-propanone-(1) HCl was obtained which after recrystallization from methanol had a MP of 190° to 193°C.

Therapeutic Function

Coronary vasodilator

in vivo

Oxyfedrine (14 mg/kg, p.o., for 3-4 weeks) shows anti-anginal action in cats^[2].
Oxyfedrine (10 mg/kg, i.p., HCT116 cell xenograft mice) suppresses tumor growth when combined with sulfasalazine (SSZ, 350 mg/kg, i.p.)^[1].
Oxyfedrine (1 mg/kg, i.v.) decreases the arterial and venous blood high blood viscosity (HBV) in ice water stress rats^[3].

References

[1] Otsuki Y, et al. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Sci. 2020 Jan;111(1):127-136. DOI:10.1111/cas.14224
[2] Parratt JR. The haemodynamic effects of prolonged oral administration of oxyfedrine, a partial agonist at beta-adrenoceptors: comparison with propranolol. Br J Pharmacol. 1974 May;51(1):5-13. DOI:10.1111/j.1476-5381.1974.tb09625.x
[3] Yu J, et al. [Effects of oxyfedrine on high blood viscosity and myocardial necrosis induced by epinephrine and ice water stress in rats]. Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):364-6. PMID:8249637
[4] Mackenzie JE, et al. Effects of oxyfedrine on isolated portal vein and other smooth muscles. Br J Pharmacol. 1973 Apr;47(4):827-37. DOI:10.1111/j.1476-5381.1973.tb08210.x

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Shaanxi Dideu Medichem Co. Ltd

Product: Oxyfedrine hydrochloride 16777-42-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

Career Henan Chemical Co

Product: [R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride 16777-42-7
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

16777-42-7, [R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Related Search:

Olopatadine hydrochloride Oxyfedrine Methoxypropiophenone 3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride

(3R)-3-(((1S)-1-Hydroxy-1-phenylpropan-2-yl)amino)-3-methoxy-1-phenylpropan-1-one hydrochloride

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride

OXYFEDRINE HCL

OXYFEDRINEHYROCHLORIDE

L-OXYFEDRINE HCL

D 563

FDA 1576

Ildamen

l-Oxyfedrine hydrochloride

Modacor

L-Form hydrochloride

3-[[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-(3-methoxyphenyl)-1-propanone hydrochloride

Ildamen USP/EP/BP

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride USP/EP/BP

3-[[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-(3-methoxyphenyl)propan-1-one,hydrochloride

Oxyfedrine L-form HCl

Oxyfedrine L-form hydrochloride

Oxyfedrine L-form HCl, 10 mM in DMSO

1-Propanone, 3-[[(1S,2R)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-(3-methoxyphenyl)-, hydrochloride (1:1)

16777-42-7

C19H23NO3ClH

C19H23NO3HCl

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Property

Safety

Hazard and Precautionary Statements (GHS)

N-Bromosuccinimide Price

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Chemical Properties,Usage,Production

Originator

Uses

Manufacturing Process

Therapeutic Function

in vivo

References

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Suppliers

View Lastest Price from [R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride manufacturers

16777-42-7, [R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Related Search:

[R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride

[R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Property

[R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Chemical Properties,Usage,Production

[R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Preparation Products And Raw materials

[R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Suppliers

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16777-42-7, [R-(R,S)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Related Search: