Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-

Product Name: Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-
CAS No.: 2313525-90-3
Chemical Name: Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-
Synonyms: Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-;HepG2 cells,inhibit,thiol hydrolases,LEI110,Inhibitor,LEI-110,lipolysis,Phospholipase,LEI 110
CBNumber: CB78843943
Molecular Formula: C25H23F3N2O3
Formula Weight: 456.47
MOL File: 2313525-90-3.mol

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Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Property

Density: 1.247±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Ethanol: soluble
form: A solid
pka: 12.15±0.46(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Chemical Properties,Usage,Production

Biological Activity

LEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2; IC50 = 100 nM).1 It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT; IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 μM) decreases arachidonic acid levels in U2OS cells expressing human AdPLA2 and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.

References

1.Zhou, J., Mock, E.D., Martella, A., et al.Activity-based protein profiling identifies α-ketoamides as inhibitors for phospholipase A2 group XVIACS Chem. Biol.14(2)164-169(2019)

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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2313525-90-3, Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-Related Search:

Benzenepentanamide, α-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-

HepG2 cells,inhibit,thiol hydrolases,LEI110,Inhibitor,LEI-110,lipolysis,Phospholipase,LEI 110

2313525-90-3