sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
- Product Name
- sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
- CAS No.
- 41733-55-5
- Chemical Name
- sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate
- Synonyms
- Fursemide sodium;Frusemide Sodium;Sodium furosemide;FuroseMide (sodiuM);Furosemide sodium, 10 mM in DMSO;Sodium 5-(aminosulfonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate;sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate;5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid sodium salt
- CBNumber
- CB7886067
- Molecular Formula
- C12H12ClN2NaO5S
- Formula Weight
- 354.74
- MOL File
- 41733-55-5.mol
sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 150 mg/mL (425.25 mM)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-1916
- Product name
- Furosemidesodium
- Purity
- 99.69%
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-1916
- Product name
- Furosemidesodium
- Purity
- 99.69%
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate Chemical Properties,Usage,Production
Uses
Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl-(NKCC) cotransporter, NKCC1 and NKCC2[1].Furosemide sodium is also a GABAAreceptors antagonist and displays 100-fold selectivity forα6-containing receptors thanα1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].
in vivo
Furosemide sodium (intraperitoneal injection; 100 mg/kg; single dose) is injected after kanamycin (KM) (1000 mg/kg) to creat a deaf mouse model in C57BL/6 mouse. After injection, hearing loss and cochlear hair cell damage are evaluated on day 1, day 2 and day 3, respectively. The hearing is markedly deteriorated even from the next day (Day-1 group), OHCs (outer hair cell) morphology of apical, middle and basal turns are disorganized in mice on day3[1].
References
[1] C M Gillen, et al. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. J Biol Chem. 1996 Jul 5;271(27):16237-44. DOI:10.1074/jbc.271.27.16237
[2] S A Thompson, et al. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by Furosemide sodium. Mol Pharmacol. 1999 Jun;55(6):993-9. DOI:10.1124/mol.55.6.993
[3] Shin Hye Kim, et al. Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide sodium-Treated Mice. Front Cell Neurosci.2018 Jan 19;12:3. DOI:10.3389/fncel.2018.00003
[4] Atsushi Shiozaki, et al. Furosemide sodium, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state. J Physiol Sci.2006 Dec;56(6):401-6. DOI:10.2170/physiolsci.RP010806
[5] Yuliya V Kucherenko, et al.Inhibitory effect of Furosemide sodium on non-selective voltage-independent cation channels in human erythrocytes.Cell Physiol Biochem. 2012;30(4):863-75. DOI:10.1159/000341464
sodium 5-(aminosulphonyl)-4-chloro-2-(furan-2-ylmethyl)anthranilate Preparation Products And Raw materials
Raw materials
Preparation Products
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