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tolciclate

Product Name
tolciclate
CAS No.
50838-36-3
Chemical Name
tolciclate
Synonyms
K 9147;KC 9147;Fungifos;Tolmicen;Kilmicen;Aids029681;Aids-029681;1,4-Methanonaphthalene, carbamothioic acid deriv.;N-Methyl-N-(m-tolyl)thiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester;N-(3-Methylphenyl)-N-methylthiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
CBNumber
CB7893256
Molecular Formula
C20H21NOS
Formula Weight
323.45
MOL File
50838-36-3.mol
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tolciclate Property

Melting point:
92-94°
Boiling point:
447.3±55.0 °C(Predicted)
Density 
1.0965 (rough estimate)
refractive index 
1.5800 (estimate)
pka
-0.42±0.50(Predicted)
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Safety

Toxicity
LD50 in mice, rats, dogs (mg/kg): 4000, 6000, 5000 orally (deCarneri)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0004442
Product name
TOLCICLATE
Purity
95.00%
Packaging
5MG
Price
$496.07
Updated
2021/12/16
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tolciclate Chemical Properties,Usage,Production

Originator

Tolmicen,Carlo Erba,Italy,1979

Definition

ChEBI: Tolciclate is a monothiocarbamic ester. It has a role as an antifungal drug.

Indications

The indications for tolciclate are defined by its narrow spectrum and limited to the treatment of dermatophytoses. Because of inadequate penetration into the nail keratin, it is unlikely to be effective for the treatment of onychomycoses. On average, the efficacy of tolciclate in topical therapy of dermatomycoses is lower than that of most other antimycotics for topical treatment.

Manufacturing Process

Thiophosgene (1.15 g, 0.01 mol) in chloroform (40 ml) was slowly treated at room temperature with sodium 1,4-methano-1,2,3,4-tetrahydro-6- naphthoxide (1.82 g, 0.01 mol). After 30 minutes, N-methyl-m-toluidine (2.42 g, 0.02 mol) in chloroform (40 ml) was added dropwise to the solution so obtained at room temperature. The reaction mixture was stirred for 48 hours at room temperature and then refluxed for 2 hours. The solvent was evaporated, and the residue redissolved in water and extracted repeatedly with diethyl ether. The organic phase was dried (Na2SO4) and evaporated to dryness to give, after crystallization from isopropanol, O-(1,4-methano- 1,2,3,4-tetrahydro-6-naphthyl)-N-methyl-N-(m-tolyl)-thiocarbamate (1.3 g) melting point 92°C to 94°C.

Therapeutic Function

Topical antimycotic

Antimicrobial activity

In vitro, tolciclate has a narrow activity spectrum with good efficacy only towards dermatophytes. Isolates of susceptible species showing primary resistance or developing secondary resistance are rarely observed.

tolciclate Preparation Products And Raw materials

Raw materials

Preparation Products

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tolciclate Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19704
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58

50838-36-3, tolciclateRelated Search:


  • 1,4-Methanonaphthalene, carbamothioic acid deriv.
  • Carbamothioic acid, methyl(3-methylphenyl)-, O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester (9CI)
  • Fungifos
  • K 9147
  • KC 9147
  • Kilmicen
  • Tolmicen
  • N-(3-Methylphenyl)-N-methylthiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
  • N-(3-Methylphenyl)-N-methylthiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalenanonaphthalen-6-yl)
  • N-Methyl-N-(m-tolyl)thiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
  • Aids029681
  • Aids-029681
  • Carbamothioic acid, methyl(3-methylphenyl)-, o-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
  • Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl) ester
  • 50838-36-3