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laudanosine

Product Name
laudanosine
CAS No.
2688-77-9
Chemical Name
laudanosine
Synonyms
Nsc 35045;Einecs 220-253-2;(+)-(S)-Laudanosine;Cisatracurium Besylate Impurity 49;(S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline;(1S)-1,2,3,4-Tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinoline;[1S,(+)]-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline;Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-
CBNumber
CB7897724
Molecular Formula
C21H27NO4
Formula Weight
357.44
MOL File
2688-77-9.mol
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laudanosine Property

Melting point:
89°
alpha 
D16 +106° (c = 1.6 in 97% alc); D16 +130° (chloroform); D22 +52.2 ±1.3° (chloroform); D20 +82.5° (ethanol)
Boiling point:
490.07°C (rough estimate)
Density 
1.1729 (rough estimate)
refractive index 
1.5614 (estimate)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)
form 
White to Pale Beige
pka
7.80±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Cayman Chemical
Product number
27170
Product name
(S)-Laudanosine
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
27170
Product name
(S)-Laudanosine
Packaging
5mg
Price
$319
Updated
2024/03/01
TRC
Product number
L178525
Product name
(S)-Laudanosine
Packaging
50mg
Price
$1695
Updated
2021/12/16
AK Scientific
Product number
4558CA
Product name
N-Methyltetrahydropapaverine
Packaging
5mg
Price
$452
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
MTB0000505
Product name
LAUDANOSINE
Purity
95.00%
Packaging
5MG
Price
$496.9
Updated
2021/12/16
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laudanosine Chemical Properties,Usage,Production

Uses

Laudanosine is a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.

Definition

ChEBI: Laudanosine is a member of isoquinolines.

Purification Methods

Crystallise these from EtOH. The (±)-picrate crystallises from EtOH with m 177-178o. The (-)-isomer has m 83-85o and

laudanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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laudanosine Suppliers

Canada 1 China 21 India 1 United Kingdom 1 United States 5 Global 29

2688-77-9, laudanosine Related Search:

Cisatracurium Besilate EP Impurity W Iodide (Mixture of Diastereomers) Cisatracurium Besilate EP Impurity N and O Iodide (Mixture of Diastereomers) Atracurium EP Impurity D Iodide (Mixture of Diastereomers) Atracurium Impurity 1 (R-trans, R-trans)-AtracuriuM Besylate PHENYL P-TOLYL SULFONE Atracurium Impurity 27 Besylate Atracurium EP Impurity K Iodide (Mixture of Diastereomers) Atracurium Impurity 15 Atracurium Impurity 19 AtracuriuM IMpurity A1 (trans-Monoquatenary) Atracurium Impurity 34 Iodide Cisatracurium Besilate EP Impurity T Iodide Atracurium Impurity 30 Besylate Atracurium Impurity 12 Iodide (Mixture of Diastereomers) Atracurium Impurity 24 1-(3,4-dimethoxy-benzyl)-7,8-dimethoxy-1,2,3,4-tetrahydro-isoquinoline Atracurium Impurity 37 Besylate

  • (+)-(S)-Laudanosine
  • (1S)-1,2,3,4-Tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinoline
  • [1S,(+)]-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline
  • Einecs 220-253-2
  • Nsc 35045
  • Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, (1S)-
  • (S)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
  • Cisatracurium Besylate Impurity 49
  • 2688-77-9
  • Alkaloids
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Aromatics, Chiral Reagents, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals