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2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-

Product Name
2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
CAS No.
2417718-25-1
Chemical Name
2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
Synonyms
VT-104;VT104, 10 mM in DMSO;(S)-N-[1-(2-Pyridyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthamide;(S)-N-(1-(Pyridin-2-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-2-naphthamide;N-[(1S)-1-(pyridin-2-yl)ethyl]-5-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxamide;2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
CBNumber
CB79021542
Molecular Formula
C25H19F3N2O
Formula Weight
420.43
MOL File
2417718-25-1.mol
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2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]- Property

Boiling point:
583.3±50.0 °C(Predicted)
Density 
1.259±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 2mg/mL, clear
form 
Solid
pka
13.30±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3445
Product name
VT104
Purity
≥98% (HPLC)
Packaging
5MG
Price
$106.4
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3445
Product name
VT104
Purity
≥98% (HPLC)
Packaging
25MG
Price
$428.45
Updated
2025/07/31
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2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]- Chemical Properties,Usage,Production

Description

VT-104 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT104 is an analog of VT102, which has improved potency and good oral pharmacokinetics in mice. VT104 prevented palmitoylation of the TEAD1 protein. VT104 showed excellent orally bioavailability and long half-lives, which inhibits tumor growth and also lead to shrinkage of established tumors in preclinical models of human mesothelioma CDX models deficient in functional Merlin.

Uses

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer[1][2].

in vivo

VT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts[1].

Animal Model:NCI-H226-tumor bearing mice[1]
Dosage:0.3, 1, and 3 mg/kg
Administration:Oral administration
Result:Blocked NCI-H226 tumor growth in mice in dose-dependent manner.

References

[1] Tang TT, et, al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998. DOI:10.1158/1535-7163.MCT-20-0717
[2] Barry ER, et, al. Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine. Cells. 2021 Oct 11;10(10):2715. DOI:10.3390/cells10102715

2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]- Suppliers

China 27 United States 1 Global 28
ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Shanghai Chaolan Chemical Technology Center
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Bide Pharmatech Ltd.
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2417718-25-1, 2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-Related Search:


  • 2-Naphthalenecarboxamide, N-[(1S)-1-(2-pyridinyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-
  • VT-104
  • N-[(1S)-1-(pyridin-2-yl)ethyl]-5-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxamide
  • VT104, 10 mM in DMSO
  • (S)-N-[1-(2-Pyridyl)ethyl]-5-[4-(trifluoromethyl)phenyl]-2-naphthamide
  • (S)-N-(1-(Pyridin-2-yl)ethyl)-5-(4-(trifluoromethyl)phenyl)-2-naphthamide
  • 2417718-25-1