methyl ibogamine-18-carboxylate

Product Name: methyl ibogamine-18-carboxylate
CAS No.: 467-77-6
Chemical Name: methyl ibogamine-18-carboxylate
Synonyms: NSC 127490;Coronaridin;coronardine;methyl ibogamine;methyl ibogamine-18-carboxylate;Ibogamine-18-carboxylic acid methyl ester;(-)-Ibogamine-18-carboxylic acid methyl ester
CBNumber: CB7912456
Molecular Formula: C21H26N2O2
Formula Weight: 338.448
MOL File: 467-77-6.mol

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methyl ibogamine-18-carboxylate Property

Melting point:: 92-93 °C
Boiling point:: 488.1±45.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
pka: 16?+-.0.60(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN92859
Product name: Coronaridine
Purity: ≥98%
Packaging: 5mg
Price: $488
Updated: 2021/12/16

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methyl ibogamine-18-carboxylate Chemical Properties,Usage,Production

Uses

Ibogamine-18-carboxylic Acid Methyl Ester (CAS# 467-77-6) is a useful research chemical compound. It is used in the biosynthesis of anti-addiction agent from iboga plant.

Definition

ChEBI: (-)-coronaridine is a monoterpenoid indole alkaloid with formula C21H26N2O2. It is isolated from the flowering plant genus, Tabernaemontana. It has a role as an antileishmanial agent, an antineoplastic agent, an apoptosis inducer and a plant metabolite. It is a monoterpenoid indole alkaloid, a methyl ester, an organic heteropentacyclic compound and an alkaloid ester. It is a conjugate base of a (-)-coronaridine(1+).

Biological Activity

Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression[1]. Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC50 values >40 μM. It agaisnt wnt-dependent cells with IC50 values of 10.4, 11.6 and 24.4 μM for SW480, HCT116 and DLD1cells, respectively[1].Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β--catenin at Ser33, Ser37, and Thr41 and p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged[1].In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC30 value for each receptor subtype. Both congeners potentiated different GABAARs in a concentration-dependent manner[2].At higher concentrations, however, Catharanthine starts to inhibit GABA-activated currents due to the reduced amplitude and rebound current, where the threshold concentration depended on the receptor subtype (e.g., > 30 μM for hα1β2; > 100 μM for hα1β2γ2 and hα2β2γ2). The PAM activity of Catharanthine's are depended on the receptor subtype: hα1β2 (4.6±0.8 μM), >hα2β2γ2 (12.6±3.8 μM), hα1β2γ2 (14.4 ± 4.6 μM)[2].

References

[1]. Kensuke Ohishi, et al. Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits the Wnt signaling pathway by decreasing β-catenin mRNA expression. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3937-40. [2]. Hugo R Arias, et al. Coronaridine congeners potentiate GABA A receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jul 13;101:109930

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View Lastest Price from methyl ibogamine-18-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: methyl ibogamine 467-77-6
Price: US $1.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2024-07-25

Shaanxi Dideu Medichem Co. Ltd

Product: Coronaridin 467-77-6
Price: US $1.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2024-07-25

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methyl ibogamine-18-carboxylate

coronardine

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Ibogamine-18-carboxylic acid methyl ester

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NSC 127490

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467-77-6