metixene
- Product Name
- metixene
- CAS No.
- 4969-02-2
- Chemical Name
- metixene
- Synonyms
- Trest;Tremonil;Tremaril;Methixene;Methixart;60 SJ 1977;Aids-001633;115511-20-1 (3S);115511-21-2 (3R);metixene USP/EP/BP
- CBNumber
- CB7918610
- Molecular Formula
- C20H23NS
- Formula Weight
- 309.47
- MOL File
- 4969-02-2.mol
metixene Property
- Melting point:
- <25 °C
- Boiling point:
- bp0.07 171-175°
- Density
- 1.118±0.06 g/cm3(Predicted)
- pka
- 9.46±0.10(Predicted)
- NIST Chemistry Reference
- Piperidine, 1-methyl-3-(9h-thioxanthen-9-ylmethyl)-(4969-02-2)
Safety
- Toxicity
- LD50 oral in mouse: 430mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- API0009179
- Product name
- METIXENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $550
- Updated
- 2021/12/16
metixene Chemical Properties,Usage,Production
Originator
Tremarit Wander W. Germany,Wander ,W. Germany,1960
Definition
ChEBI: Metixene is a member of thioxanthenes and a member of piperidines. It has a role as an antiparkinson drug, a muscarinic antagonist and a histamine antagonist.
Manufacturing Process
To 4.9 g of finely pulverized sodium in 50 ml of absolute benzene add dropwise with stirring 12 g of chlorobenzene in 50 ml of absolute benzene. As soon as the exothermic reaction begins, maintain the temperature by cooling between 30° and 35°C, and continue stirring for 2 to 3 hours. To the resulting phenyl sodium add dropwise 19.8 g of thioxanthene in 120 ml of absolute benzene. The slightly exothermic reaction ceases after about 1 to 1? hours.
To this newly formed 9-thioxanthyl sodium add dropwise, with stirring and cooling, 13.1 g of N-methyl-3-chloromethyl-piperidine in 30 to 40 ml of absolute benzene, then continue stirring at about 25°C for 1? hours, and heat subsequently to 40°C for 1 hour. Decompose the resulting mixture by adding carefully a small amount of water, and then extract the newly formed base from the benzene solution by means of dilute hydrochloric acid. The aqueous hydrochloric solution is made alkaline by adding dilute sodium hydroxide, and the thioxanthene base is isolated by extraction with ether. This results in 22 g of a slightly yellow, viscous base of BP 171° to 175°C/0.07 mm.
The base is acidified with alcoholic hydrochloric acid. Alcohol-ether (1:2) is then added and the hydrochloride salt is crystallized as colorless flakes melting at 211° to 213°C.
Therapeutic Function
Spasmolytic
metixene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from metixene manufacturers
- Product
- metixene 4969-02-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-27