ChemicalBook > CAS DataBase List > 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
- Product Name
- 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
- CAS No.
- 5424-37-3
- Chemical Name
- 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride
- Synonyms
- Surfen;Surfen (NSC-12155);Surfen dihydrochloride;NSC-12155 (surfen hydrate);Aminoquinuride hydrochloride;Aminokinuride dihydrochloride;Aminoquinuride dihydrochloride;Aminoquincarbamide dihydrochloride;1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride;1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride
- CBNumber
- CB7922378
- Molecular Formula
- C21H22Cl2N6O
- Formula Weight
- 445.34498
- MOL File
- 5424-37-3.mol
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1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Off-white to gray
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N-Bromosuccinimide Price
Tocris
- Product number
- 6634
- Product name
- Surfen
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $104
- Updated
- 2021/12/16
Tocris
- Product number
- 6634
- Product name
- Surfen
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $405
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB139214
- Product name
- Surfen
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
AK Scientific
- Product number
- SYN5360
- Product name
- NSC-12155
- Packaging
- 10mg
- Price
- $235
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB139214
- Product name
- Surfen
- Packaging
- 50mg
- Price
- $437.5
- Updated
- 2021/12/16
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1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Chemical Properties,Usage,Production
Uses
Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].
IC 50
FGFR2: 5 μM (IC50); HSV-1
storage
Store at -20°C
References
[1] Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80. DOI:10.1073/pnas.0805862105
1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochloride Suppliers
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5424-37-3, 1,3-bis(4-amino-2-methyl-6-quinolyl)urea dihydrochlorideRelated Search:
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