[2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Product Name: [2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS No.: 304-43-8
Chemical Name: [2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Synonyms: Ancillin;Diphenicillin;Biphenicillin;([1,1'-Biphenyl]-2-yl)penicillin;6α-(2-Biphenylylcarbonylamino)penicillanic acid;6α-[([1,1'-Biphenyl]-2-ylcarbonyl)amino]penicillanic acid;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylbenzoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2S,5R,6R)-7-keto-3,3-dimethyl-6-[(2-phenylbenzoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylphenyl)carbonylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[([1,1'-biphenyl]-2-ylcarbonyl)amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
CBNumber: CB7923865
Molecular Formula: C21H20N2O4S
Formula Weight: 396.46
MOL File: 304-43-8.mol

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[2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Property

Density: 1.2270 (rough estimate)
refractive index: 1.6930 (estimate)

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Safety

Toxicity: LD50 orl-mus: 5600 mg/kg 85ERAY 3,1663,78

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0025480
Product name: BIPHENICILLIN
Purity: 95.00%
Packaging: 5MG
Price: $499.24
Updated: 2021/12/16

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[2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical Properties,Usage,Production

Uses

Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a Penicillinase (HY-E70012)- resistant penicillin with antibacterial activity. Diphenicillin shows good antibacterial effects against Gram-positive cocci. Diphenicillin is promising for research of infectious diseases caused by Gram-positive cocci such as staphylococci, pneumococci, and group A streptococci[1][2].

Safety Profile

Moderately toxic by intravenousroute. Mildly toxic by ingestion. When heated todecomposition it emits very toxic fumes of NOx and SOx.See other penicillin entries.

References

[1] WEBER RG, et al. Clinical and laboratory studies of sodium diphenicillin. II. Clinical studies, with emphasis on the rate of disappearance of staphylococci from various lesions. Arch Intern Med. 1963 Jun;111:756-61. DOI:10.1001/archinte.1963.03620300076013
[2] Rudzit é A, et al. Ancillin. Synthesis and properties[J]. Pharmaceutical Chemistry Journal, 1967, 1(5): 245-246.

[2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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[2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Suppliers

China 3 South Korea 1 United States 1 Global 5

BOC Sciences

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Country: United States
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Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 18679456698
Email: mingxinzhu@huidabiotech.com
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Zhejiang Huida Biotech Co., LTD

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Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

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304-43-8, [2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acidRelated Search:

Diphenicillin sodium [2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

[2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Biphenicillin

([1,1'-Biphenyl]-2-yl)penicillin

6α-(2-Biphenylylcarbonylamino)penicillanic acid

6α-[([1,1'-Biphenyl]-2-ylcarbonyl)amino]penicillanic acid

Ancillin

(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylbenzoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylphenyl)carbonylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

(2S,5R,6R)-7-keto-3,3-dimethyl-6-[(2-phenylbenzoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[([1,1'-biphenyl]-2-ylcarbonyl)amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-

Diphenicillin

304-43-8