5,5'-isopropylidenebis(m-xylene-2,alpha,alpha'-triol) Property

Boiling point:

564.8±45.0 °C(Predicted)

Density 

1.367±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

10.27±0.10(Predicted)

color 

White to Off-White

EPA Substance Registry System

1,3-Benzenedimethanol, 5,5'-(1-methylethylidene)bis[2-hydroxy- (3957-22-0)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5,5'-isopropylidenebis(m-xylene-2,alpha,alpha'-triol) Chemical Properties,Usage,Production

Uses

5,5'-isopropylidenebis(m-xylene-2,alpha,alpha'-triol) can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Preparation Example 3. 2,2-bis[4-trimethylsilyloxy-3,5-bis(trimethylsilyloxymethyl)-phenyl]propane (monomer K). a) 2,2-bis[4-hydroxy-3,5-di(hydroxymethyl)phenyl)]propane. 114.4 of bisphenol A (2,2-bis[4-hydroxyphenyl)]propane) were initially charged in a mixture of 450 g of water and 50 g of NaOH. While cooling (Tmax=25°C), 350 g of 30% formaldehyde solution were added dropwise. After continued reaction at room temperature for 1 h, a clear solution was obtained. The mixture was neutralized by adding solid CO2. The resulting solution was saturated with sodium chloride and extracted 3 times with butanol. The extracts were concentrated on a rotary evaporator at 50°C down to 5 mbar. The product was used in the next step without further purification. colorless oil. 1H-NMR 400 MHz, CDCl3, 25°C, TMS δ [ppm] = 7.03 (s, 4 H, Aromat); 5.00 (s, 6 H, -OH (breit)); 4.63 (s, 8H, -CH2-); 1.60 (s, 6 H, C-CH3).