methyl 3-methylisoxazole-5-carboxylate
Uses- Product Name
- methyl 3-methylisoxazole-5-carboxylate
- CAS No.
- 1004-96-2
- Chemical Name
- methyl 3-methylisoxazole-5-carboxylate
- Synonyms
- methyl 3-methylisoxazole-5-carboxylate;methyl 3-methyl-5-isoxazolecarboxylate;Methyl 3-methyl-1,2-oxazole-5-carboxylate;3-Methylisoxazole-5-carboxylic acid methyl ester;3-Methyl-5-isoxazolecarboxylic acid methyl ester;5-Isoxazolecarboxylicacid, 3-methyl-, methyl ester
- CBNumber
- CB7928491
- Molecular Formula
- C6H7NO3
- Formula Weight
- 141.12
- MOL File
- 1004-96-2.mol
methyl 3-methylisoxazole-5-carboxylate Property
- Melting point:
- 108 °C
- Boiling point:
- 227.6±20.0 °C(Predicted)
- Density
- 1.179±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -3.24±0.50(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M338673
- Product name
- Methyl3-Methylisoxazole-5-carboxylate
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- OR950812
- Product name
- Methyl3-methylisoxazole-5-carboxylate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 0210AA
- Product name
- Methyl3-methylisoxazole-5-carboxylate
- Packaging
- 1g
- Price
- $181
- Updated
- 2021/12/16
- Product number
- OR950812
- Product name
- Methyl3-methylisoxazole-5-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 35441
- Product name
- Methyl3-methylisoxazole-5-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $492
- Updated
- 2021/12/16
methyl 3-methylisoxazole-5-carboxylate Chemical Properties,Usage,Production
Uses
3-Methylisoxazole-5-carboxylic acid methyl ester is a heterocyclic compound used as a reagent in organic synthesis and as an intermediate in the synthesis of other compounds. It is commonly used in the laboratory.
Synthesis Reference(s)
Synthesis, p. 837, 1977 DOI: 10.1055/s-1977-24593
Synthesis
107-29-9
922-67-8
1004-96-2
N-chlorosuccinimide (2.67 g, 20 mmol) and pyridine (0.1 mL) were dissolved in chloroform (18 mL) at 5 °C, followed by the addition of glyoxime (1.18 g, 20 mmol) in batches. After the addition was completed, the reaction mixture was stirred at room temperature for 10 min, after which methyl propargylate (2.22 mL, 25 mmol) was added. Next, a chloroform (3 mL) solution of triethylamine (2.92 mL, 21 mmol) was added dropwise at a controlled rate of 15-18 °C. Upon completion of the dropwise addition, the reaction mixture was continued to be stirred at 18 °C for 20 min, followed by the addition of water (15 mL) for quenching. The organic layer was separated and washed with 15 mL of water and subsequently dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was treated with ether (20 mL) and the resulting precipitate was collected by filtration and dried to give methyl 3-methylisoxazole-5-carboxylate (1.75 g, 12.4 mmol, 62% yield) as a brown solid, which was used directly in the next step of the reaction. The product was characterized by 1H-NMR (CDCl3, Bruker 400MHz): δ 2.38 (3H, s); 3.96 (3H, s); 6.80 (1H, s).
References
[1] Patent: US2014/179676, 2014, A1. Location in patent: Paragraph 0700
[2] Tetrahedron, 1994, vol. 50, # 22, p. 6643 - 6652
methyl 3-methylisoxazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl 3-methylisoxazole-5-carboxylate Suppliers
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View Lastest Price from methyl 3-methylisoxazole-5-carboxylate manufacturers
- Product
- methyl 3-methylisoxazole-5-carboxylate 1004-96-2
- Price
- US $8.00/KG
- Min. Order
- 1g
- Purity
- Min98% HPLC/GC
- Supply Ability
- g/kg/ton
- Release date
- 2020-10-28
- Product
- methyl 3-methylisoxazole-5-carboxylate 1004-96-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-07-25