ChemicalBook > CAS DataBase List > 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)

5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)

Product Name
5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)
CAS No.
604769-01-9
Chemical Name
5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)
Synonyms
CS-1048;R 306465;JNJ 16241199;R306465(JNJ-16241199);JNJ-16241199; JNJ16241199; JNJ 16241199;R 306465;JNJ16241199;R-306465;JNJ 16241199;N-Hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]-5-pyrimidinecarboxamide;N-hydroxy-2-[4-(naphthalen-2-ylsulfonyl)piperazin-1-yl]pyriMidine-5-carboxaMide;5-PyriMidinecarboxaMide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]-;5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)
CBNumber
CB7950388
Molecular Formula
C19H19N5O4S
Formula Weight
413.45
MOL File
604769-01-9.mol
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5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Property

Density 
1.466
storage temp. 
Store at 0-8 °C
form 
Solid
pka
8.10±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific
Product number
099059
Product name
N-Hydroxy-2-(4-(naphthalen-2-ylsulfonyl)-piperazin-1-yl)pyrimidine-5-carboxamide
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
Biorbyt Ltd
Product number
orb180903
Product name
R306465(JNJ-16241199)
Purity
>97%
Packaging
100mg
Price
$838.1
Updated
2021/12/16
AK Scientific
Product number
9013AB
Product name
N-Hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-1-yl)pyrimidine-5-carboxamide
Packaging
250mg
Price
$1051
Updated
2021/12/16
Biorbyt Ltd
Product number
orb180903
Product name
R306465(JNJ-16241199)
Purity
>97%
Packaging
250mg
Price
$1504.5
Updated
2021/12/16
Matrix Scientific
Product number
099059
Product name
N-Hydroxy-2-(4-(naphthalen-2-ylsulfonyl)-piperazin-1-yl)pyrimidine-5-carboxamide
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
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5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Chemical Properties,Usage,Production

Uses

JNJ-16241199 (R306465) is an orally active, selectivehydroxamate-based histone deacetylase (HDAC) inhibitor, with theIC50of 3.3 nM and 23 nM for HDAC1and HDAC8, respectively.JNJ-16241199induces histone 3 acetylation and strongly increases the expression of p21waf1, cip1 in A2780 ovarian carcinoma cells.JNJ-16241199 inducescell apoptosisand shows anticancer activityin a broad spectrum of human malignancies. JNJ-16241199 can be used for cancer study[1].

in vivo

JNJ-16241199 (R306465) inhibits proliferation in acute lymphoblastic leukaemia (ALL), AML, chronic lymphoblastic leukaemia (CLL), chronic myeloid leukaemia (CML), lymphoma and myeloma tumour cells (IC50 values = 15–486 nM) [1].
JNJ-16241199 inhibits the primary human mammary epithelial cell (HMEC) proliferation with the IC50 of 32 nM, and is insensitive to quiescent, non-proliferative HMEC cells (IC50 = 7815 nM) [1].
JNJ-16241199 (0.1, 0.3, 1 μM, 24-48 h) induces apoptosis and inhibits angiogenesis in A2780 cell line[1].

Animal Model:Human A2780, H460 and HCT116 orthotopic xenograft tumor models[1]
Dosage:10-40 mpk/day for 28 days
Administration:Oral gavage (p.o.)
Result:Induced H3 acetylation and p21waf1, cip1 promoter activity in A2780 ovarian tumour tissue.
Decreased tumour volume in three orthotopic xenograft tumor models.
Reached maximal decrease in final tumour volume to 76–87% in human A2780 orthotopic xenograft tumor models.

IC 50

HDAC1: 3.3 nM (IC50); HDAC8: 23 nM (IC50)

References

[1] Arts J, et al. R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. Br J Cancer. 2007;97(10):1344-1353. DOI:10.1038/sj.bjc.6604025

5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) Suppliers

China 27 United States 4 Global 31
QINGDAO CARELONGPHARMATECH CO.,LTD
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0532-0532-88191853 13061484198
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China
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+86 21 61551611
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+86 21 50676805
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View Lastest Price from 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) manufacturers

Career Henan Chemical Co
Product
5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI) 604769-01-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

604769-01-9, 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)Related Search:


  • 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]- (9CI)
  • 5-PyriMidinecarboxaMide, N-hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]-
  • JNJ 16241199
  • N-Hydroxy-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]-5-pyrimidinecarboxamide
  • R 306465
  • N-hydroxy-2-[4-(naphthalen-2-ylsulfonyl)piperazin-1-yl]pyriMidine-5-carboxaMide
  • R306465(JNJ-16241199)
  • JNJ-16241199; JNJ16241199; JNJ 16241199
  • 2-[4-(Naphthalene-2-sulfonyl)-piperazin-1-yl]-pyrimidine-5-carboxylic acid hydroxyamide
  • R 306465;JNJ16241199;R-306465;JNJ 16241199
  • CS-1048
  • 604769-01-9