3-Amino-5-hydroxybenzoic acid hydrochloride
- Product Name
- 3-Amino-5-hydroxybenzoic acid hydrochloride
- CAS No.
- 14206-69-0
- Chemical Name
- 3-Amino-5-hydroxybenzoic acid hydrochloride
- Synonyms
- 3-AMINO-5-HYDROXYBENZOIC ACID HCL;3-Amino-5-hydroxybenzoic acid hydrochloride;3-Amino-5-hydroxybenzoicacidhydrochloride95%;3-Amino-5-hydroxybenzoic acid hydrochloride 95%;Benzoic acid, 3-amino-5-hydroxy-, hydrochloride (1:1);3-Amino-5-hydroxybenzoic acid, Hydrochloric Acid Salt;3-aMino-5-hydroxybenzoic acid hydrochloride hydrate, 95%;3-Carboxy-5-hydroxyanilne hydrochloride, 3-Amino-5-carboxyphenol hydrochloride
- CBNumber
- CB7957145
- Molecular Formula
- C7H8ClNO3
- Formula Weight
- 189.59632
- MOL File
- 14206-69-0.mol
3-Amino-5-hydroxybenzoic acid hydrochloride Property
- Melting point:
- 269-272 °C (decomp)
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C7H7NO3.ClH/c8-5-1-4(7(10)11)2-6(9)3-5;/h1-3,9H,8H2,(H,10,11);1H
- InChIKey
- CXESTILCPSBCGQ-UHFFFAOYSA-N
- SMILES
- C1(C(=O)O)=CC(=CC(N)=C1)O.Cl
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 22-26-36/37/39
- Hazard Note
- Harmful
- HS Code
- 2922290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A612335
- Product name
- 3-Amino-5-hydroxybenzoicacid,HydrochloricAcidSalt
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- P000657441
- Product name
- 3-Amino-5-hydroxybenzoic acid hydrochloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- P000657441
- Product name
- 3-Amino-5-hydroxybenzoic acid hydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
- Product number
- 6925AA
- Product name
- 3-Amino-5-hydroxybenzoicacidhydrochloride
- Packaging
- 1g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- P000657441
- Product name
- 3-Amino-5-hydroxybenzoic acid hydrochloride
- Purity
- 97%
- Packaging
- 10g
- Price
- $99
- Updated
- 2021/12/16
3-Amino-5-hydroxybenzoic acid hydrochloride Chemical Properties,Usage,Production
Uses
3-Amino-5-hydroxybenzoic acid, HCl
Synthesis
99-10-5
14206-69-0
Step 1: Synthesis of 3-amino-5-hydroxybenzoic acid hydrochloride A mixture of 3,5-dihydroxybenzoic acid (250.0 g), ammonium chloride (213.0 g) and 28% ammonium hydroxide solution (750.0 mL) was placed in an autoclave and the reaction was stirred at 180 °C for 3 days. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The concentrated residue was dissolved in 6N hydrochloric acid solution (3.0 L) and the reaction mixture was heated at 100 °C for 24 hours. After that, the reaction mixture was cooled to 70°C~80°C, decolorized by adding activated carbon (30.0 g) and subsequently filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure and the resulting residue was washed twice with 6N hydrochloric acid solution and finally dried under reduced pressure to give 192.0 g of 3-amino-5-hydroxybenzoic acid hydrochloride (yield: 62.4%). 1H-NMR (d6-DMSO) δ 7.81 (s, 1H), 7.69 (s, 1H), 7.56 (s, 1H).
References
[1] Journal of the American Chemical Society, 2010, vol. 132, # 36, p. 12757 - 12765
[2] Patent: US2012/178765, 2012, A1. Location in patent: Page/Page column 11
[3] Synthetic Communications, 1999, vol. 29, # 8, p. 1379 - 1382
[4] Tetrahedron, 1983, vol. 39, # 24, p. 4189 - 4192
[5] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 7, p. 2242 - 2252
3-Amino-5-hydroxybenzoic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-5-hydroxybenzoic acid hydrochloride Suppliers
- Tel
- 021-50795510 4000665055
- syeu@accelachem.com
- Country
- China
- ProdList
- 11015
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60