ChemicalBook > CAS DataBase List > 5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine

5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine

Product Name
5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine
CAS No.
89292-91-1
Chemical Name
5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine
Synonyms
5-(4-METHYLPIPERAZIN-1-YL)-4H-1,2,4-TRIAZOL-3-AMINE;5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine;1H-1,2,4-Triazol-3-amine, 5-(4-methyl-1-piperazinyl)-;1H-1,2,4-Triazol-3-amine,5-(4-methyl-1-piperazinyl)-(9CI)
CBNumber
CB7958445
Molecular Formula
C7H14N6
Formula Weight
182.23
MOL File
89292-91-1.mol
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5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine Property

Boiling point:
392.7±52.0 °C(Predicted)
Density 
1.303±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
12.73±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AstaTech
Product number
63130
Product name
5-(4-METHYLPIPERAZIN-1-YL)-1H-1,2,4-TRIAZOL-3-AMINE
Purity
97%
Packaging
1G
Price
$182
Updated
2026/04/30
Matrix Scientific
Product number
076357
Product name
5-(4-Methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine
Packaging
1.00g
Price
$416
Updated
2026/05/18
Matrix Scientific
Product number
076357
Product name
5-(4-Methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine
Packaging
5.00g
Price
$1078
Updated
2026/05/18
Matrix Scientific
Product number
076357
Product name
5-(4-Methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine
Packaging
10.00g
Price
$1607
Updated
2026/05/18
aablocks
Product number
AA00403C
Product name
5-(4-Methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine
Purity
≥95%
Packaging
250mg
Price
$39
Updated
2026/05/28
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5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine Chemical Properties,Usage,Production

Synthesis

109-01-3

10191-60-3

89292-91-1

GENERAL METHOD: A mixed solution of N-cyanoimido-S,S-dimethyl dithiocarbonate (17.4 mmol), acetonitrile (10 mL) and N-methylpiperazine (17.4 mmol) was heated and refluxed for 2 hours. After the reaction was completed, it was cooled to room temperature, hydrazine monohydrate (25.6 mmol) was added, and heating and refluxing was continued for 5 hours. At the end of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting crude product was purified by recrystallization using ethyl acetate. Operating according to General Method B, the compound 3-amino-5-(4-methylpiperazinyl)-1H-1,2,4-triazole (11k) was obtained as a light yellow solid in 80% yield with a melting point of 103-104 °C. 1H NMR (200 MHz, DMSO-d6) δ: 10.95 (br s, 1H); 5.72 (br s, 2H); 3.16- 3.11 (m, 4H); 2.34-2.29 (m, 4H); 2.17 (s, 3H).

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 113, p. 11 - 27

5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine Suppliers

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89292-91-1, 5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amineRelated Search:

2-(4-BENZHYDRYLPIPERAZINO)-6-PHENYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE 5-[4-(4-FLUOROPHENYL)PIPERAZINO]-1H-1,2,4-TRIAZOL-3-AMINE 5-(4-BENZHYDRYLPIPERAZINO)-1H-1,2,4-TRIAZOL-3-AMINE 5-[4-(3-AMINO-1H-1,2,4-TRIAZOL-5-YL)PIPERAZINO]-1H-1,2,4-TRIAZOL-3-AMINE 7-PHENYL-2-(4-PHENYLPIPERAZINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE 7-(4-PHENOXYPHENYL)-2-(4-PHENYLPIPERAZINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE 5-[4-(4-CHLOROPHENYL)PIPERAZINO]-1H-1,2,4-TRIAZOL-3-AMINE 7-(4-METHOXYPHENYL)-2-(4-PHENYLPIPERAZINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE 7-(4-FLUOROPHENYL)-2-(4-PHENYLPIPERAZINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE 5-[4-(2-PYRIDINYL)PIPERAZINO]-1H-1,2,4-TRIAZOL-3-AMINE 6-(4-FLUOROPHENYL)-2-(4-PHENYLPIPERAZINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE 5-(4-PHENYLPIPERAZINO)-1H-1,2,4-TRIAZOL-3-AMINE 5-[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZINO]-1H-1,2,4-TRIAZOL-3-AMINE 5-[4-(4-METHOXYPHENYL)PIPERAZINO]-1H-1,2,4-TRIAZOL-3-AMINE 2-(4-BENZHYDRYLPIPERAZINO)-6-(4-METHOXYPHENYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE 6-(4-METHOXYPHENYL)-2-(4-PHENYLPIPERAZINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE 5-(4-BENZYLPIPERAZINO)-1H-1,2,4-TRIAZOL-3-AMINE 5-[4-(2,6-DIMETHYLPHENYL)PIPERAZINO]-1H-1,2,4-TRIAZOL-3-AMINE

  • 1H-1,2,4-Triazol-3-amine,5-(4-methyl-1-piperazinyl)-(9CI)
  • 5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine
  • 5-(4-METHYLPIPERAZIN-1-YL)-4H-1,2,4-TRIAZOL-3-AMINE
  • 1H-1,2,4-Triazol-3-amine, 5-(4-methyl-1-piperazinyl)-
  • 89292-91-1
  • PIPERIDINE
  • Heterocyclic Compounds