ChemicalBook > CAS DataBase List > 5-Methoxy-2-methyl benzeneboronic acid

5-Methoxy-2-methyl benzeneboronic acid

Product Name
5-Methoxy-2-methyl benzeneboronic acid
CAS No.
617689-07-3
Chemical Name
5-Methoxy-2-methyl benzeneboronic acid
Synonyms
(5-Methoxy-2-methylphenyl);2-Methyl-5-Methoxy-phenylboronic acid;5-Methoxy-2-methyl benzeneboronic acid;boronic acid, (5-methoxy-2-methylphenyl)-;Boronic acid, B-(5-methoxy-2-methylphenyl)-;(5-Methoxy-2-methylphenyl)boronic acid(contains varying amounts of Anhydride)
CBNumber
CB7969647
Molecular Formula
C8H11BO3
Formula Weight
165.98
MOL File
Mol file
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5-Methoxy-2-methyl benzeneboronic acid Property

Boiling point:
334.9±52.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
8.18±0.58(Predicted)
Appearance
Light brown to brown Solid
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Safety

HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
M341448
Product name
(5-Methoxy-2-methylphenyl)boronicAcid
Packaging
500mg
Price
$285
Updated
2021/12/16
Matrix Scientific
Product number
120045
Product name
(5-Methoxy-2-methylphenyl)boronic acid
Purity
95+%
Packaging
250mg
Price
$346
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BOR0000717
Product name
5-METHOXY-2-METHYLBENZENEBORONIC ACID
Purity
95.00%
Packaging
5MG
Price
$505.95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BOR0000717
Product name
5-METHOXY-2-METHYLBENZENEBORONIC ACID
Purity
95.00%
Packaging
1G
Price
$698.25
Updated
2021/12/16
Matrix Scientific
Product number
120045
Product name
(5-Methoxy-2-methylphenyl)boronic acid
Purity
95+%
Packaging
1g
Price
$864
Updated
2021/12/16
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5-Methoxy-2-methyl benzeneboronic acid Chemical Properties,Usage,Production

Uses

(5-Methoxy-2-methylphenyl)boronic Acid is used in preparation of Phenyl-substituted Imidazopyridine Amides useful in the treatment of cardiovascular and other disorders.

Synthesis

36942-56-0

617689-07-3

The general procedure for the synthesis of 5-methoxy-2-methylphenylboronic acid from 3-bromo-4-methylanisole was as follows: 2.5 M n-butyllithium (nBuLi, 1.8 mL, 4.5 mmol) was added slowly and dropwise over a period of 5 min to 2-bromo-4-methoxy-1-methylbenzene (750 mg, 3.73 mmol) in an anhydrous tetrahydrofuran (THF,) at -78 °C. 30 mL) solution. The reaction mixture was stirred at -78 °C for 20 min before adding anhydrous trimethylborate (0.62 g, 6 mmol). The reaction mixture was warmed to room temperature and kept for 2 hours. The reaction was quenched by addition of 2N hydrochloric acid (HCl, 1 mL). THF was removed by distillation under reduced pressure. the crude product was diluted with 2N HCl (100 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic phases were dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a light yellow solid product (0.43 g, 69% yield).

References

[1] Patent: US2005/245524, 2005, A1. Location in patent: Page/Page column 98-99

5-Methoxy-2-methyl benzeneboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Methoxy-2-methyl benzeneboronic acid manufacturers

Career Henan Chemical Co
Product
5-Methoxy-2-methyl benzeneboronic acid 617689-07-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

617689-07-3, 5-Methoxy-2-methyl benzeneboronic acidRelated Search:


  • 5-Methoxy-2-methyl benzeneboronic acid
  • 2-Methyl-5-Methoxy-phenylboronic acid
  • (5-Methoxy-2-methylphenyl)
  • Boronic acid, B-(5-methoxy-2-methylphenyl)-
  • (5-Methoxy-2-methylphenyl)boronic acid(contains varying amounts of Anhydride)
  • boronic acid, (5-methoxy-2-methylphenyl)-
  • 617689-07-3