ChemicalBook > CAS DataBase List > CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
- Product Name
- CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
- CAS No.
- 215923-54-9
- Chemical Name
- CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
- Synonyms
- GR 87;BDP 17;CX-546;BDP-17,CX546,GR87;CX 546, AMPA receptor potentiator;CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P;1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine;1-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidine;(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone;2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone
- CBNumber
- CB7972429
- Molecular Formula
- C14H17NO3
- Formula Weight
- 247.29
- MOL File
- 215923-54-9.mol
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CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Property
- Melting point:
- 71-73°C
- Boiling point:
- 422.8±44.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- pka
- -1.08±0.20(Predicted)
- form
- solid
- color
- white to off-white
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- C271
- Product name
- CX546
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $277
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- C271
- Product name
- CX546
- Purity
- ≥98% (HPLC), solid
- Packaging
- 50mg
- Price
- $395.6
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 5.05016
- Product name
- CX546 - CAS 215923-54-9 - Calbiochem
- Packaging
- 10MG
- Price
- $188
- Updated
- 2022/05/15
Tocris
- Product number
- 2980
- Product name
- CX546
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $150
- Updated
- 2021/12/16
Tocris
- Product number
- 2980
- Product name
- CX546
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $585
- Updated
- 2021/12/16
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CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Chemical Properties,Usage,Production
Uses
It is one of a series of AMPA modulators matergic AMPA receptors.
Uses
CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.
General Description
CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.
Biological Activity
AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats.
Biochem/physiol Actions
CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI)?in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.
storage
Store at +4°C
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P manufacturers
Career Henan Chemical Co
- Product
- CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P 215923-54-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02
215923-54-9, CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)PRelated Search:
3-Methylpiperidin-3-ol HCl
4-ETHOXY-N,N-DIETHYLBENZAMIDE
3-ethoxy-N,N-diethyl-4-hydroxybenzamide
CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P
CHEMBRDG-BB 5762406