(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
- Product Name
- (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
- CAS No.
- 2505001-62-5
- Chemical Name
- (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
- Synonyms
- SR18662 free base;(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide;(E)-3-(3,4-dichlorophenyl)-N-[2-(4-methylsulfonyl-1-piperazinyl)-2-oxoethyl]-2-propenamide;2-Propenamide, 3-(3,4-dichlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)-;(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide, 10 mM in DMSO;(E)3(3,4dichlorophenyl)N(2(4(methylsulfonyl)piperazin1yl)2oxoethyl)acrylamide,(E) 3 (3,4 dichlorophenyl) N (2 (4 (methylsulfonyl)piperazin 1 yl) 2 oxoethyl)acrylamide
- CBNumber
- CB79734453
- Molecular Formula
- C16H19Cl2N3O4S
- Formula Weight
- 420.31
- MOL File
- 2505001-62-5.mol
(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- pka
- 12.97±0.46(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide Chemical Properties,Usage,Production
Uses
SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer[1].
in vivo
SR18662 (intraperitoneal injection; 5-10 mg/kg; daily or twice daily; 5 days injection, days break, and 5 days) significantly reduces the growth of tumors in a mouse xenograft model[1].
| Animal Model: | Nude mice with DLD-1 cells[1] |
| Dosage: | 5 mg/kg; 10 mg/kg; 25 mg/kg |
| Administration: | Intraperitoneal injection; 5mg/kg daily, 5mg/kg twice a day,10 mg/kg daily, 10 mg/kg twice per day, 25mg/kg daily, and 25 mg/kg twice per day; 5 days of injections, 2 days break, and 5 days of injections |
| Result: | Caused a significant dose-dependent inhibition of xenograft growth in mice. |
References
[1] Julie Kim,et al.The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal CancerIn VitroandIn Vivo.Mol Cancer Ther.2019 Nov;18(11):1973-1984. DOI:10.1158/1535-7163.MCT-18-1366
(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide Preparation Products And Raw materials
Raw materials
Preparation Products
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