ZN-c3

Product Name: ZN-c3
CAS No.: 2376146-48-2
Chemical Name: ZN-c3
Synonyms: Zn-C3;ZNc3,ZN c3;azenosertib;Azenosertib (Zn-C3);ZN-c3, 10 mM in DMSO;1-[(7R)-7-ethyl-7-hydroxy-5,6-dihydrocyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one;(R)-2-Allyl-1-(7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one;3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1-[(7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta[b]pyridin-2-yl]-1,2-dihydro-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-;3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1-[(7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta[b]pyridin-2-yl]-1,2-dihydro-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)- (ACI)
CBNumber: CB79751089
Molecular Formula: C29H34N8O2
Formula Weight: 526.63
MOL File: 2376146-48-2.mol

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ZN-c3 Property

Boiling point:: 766.7±70.0 °C(Predicted)
Density: 1.311±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 12.91±0.20(Predicted)
color: Light yellow to yellow
InChIKey: OXTSYWDBUVRXFF-GDLZYMKVSA-N
SMILES: C1(NC2=CC=C(N3CCN(C)CC3)C=C2)=NC=C2C(=O)N(CC=C)N(C3N=C4[C@](CC)(O)CCC4=CC=3)C2=N1

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Hazard and Precautionary Statements (GHS)

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ZN-c3 Chemical Properties,Usage,Production

Uses

Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC50=3.9 nM). Azenosertib exhibits antitumor activity[1].

in vivo

Azenosertib (80 mg/kg; p.o.; 28 days) inhibits tumor growth in A427 xenograft NOD/SCID mice model^[1].
Azenosertib (10 mg/kg, p.o.) shows plasma exposure C_max of 2.1 μM, a half-time T_1/2 of 2.3 h, an AUC_{0-24 h} of 9.7 μM·h, and an oralbioavailability of F=142% in beagle dog model^[1].

Animal Model:	A427 xenograft NOD/SCID mice model^[1]
Dosage:	80 mg/kg
Administration:	p.o. for 28 days
Result:	Inhibited tumor growth.

References

[1] Huang PQ, et al. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer [published online ahead of print, 2021 Aug 23]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01121. DOI:10.1021/acs.jmedchem.1c01121

ZN-c3 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZN-c3 Suppliers

China 51 United States 1 Global 52

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
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Shanghai XinKai Chemical Technology Co., Ltd.

Tel: 021-58930698 15921516558
Fax: 86-021-58933679
Email: zhangyichao84@126.com
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
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Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
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Shanghai Biolang biotechnology Co.,Ltd

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Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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2376146-48-2, ZN-c3Related Search:

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1-[(7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta[b]pyridin-2-yl]-1,2-dihydro-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-

azenosertib

Zn-C3

ZNc3,ZN c3

3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1-[(7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta[b]pyridin-2-yl]-1,2-dihydro-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)- (ACI)

1-[(7R)-7-ethyl-7-hydroxy-5,6-dihydrocyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one

Azenosertib (Zn-C3)

(R)-2-Allyl-1-(7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

ZN-c3, 10 mM in DMSO

2376146-48-2