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ZN-c3

Product Name
ZN-c3
CAS No.
2376146-48-2
Chemical Name
ZN-c3
Synonyms
Zn-C3;ZNc3,ZN c3;azenosertib;Azenosertib (Zn-C3);ZN-c3, 10 mM in DMSO;1-[(7R)-7-ethyl-7-hydroxy-5,6-dihydrocyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one;(R)-2-Allyl-1-(7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one;3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1-[(7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta[b]pyridin-2-yl]-1,2-dihydro-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-;3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1-[(7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta[b]pyridin-2-yl]-1,2-dihydro-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)- (ACI)
CBNumber
CB79751089
Molecular Formula
C29H34N8O2
Formula Weight
526.63
MOL File
2376146-48-2.mol
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ZN-c3 Property

Boiling point:
766.7±70.0 °C(Predicted)
Density 
1.311±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
form 
Solid
pka
12.91±0.20(Predicted)
color 
Light yellow to yellow
InChIKey
OXTSYWDBUVRXFF-GDLZYMKVSA-N
SMILES
C1(NC2=CC=C(N3CCN(C)CC3)C=C2)=NC=C2C(=O)N(CC=C)N(C3N=C4[C@](CC)(O)CCC4=CC=3)C2=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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ZN-c3 Chemical Properties,Usage,Production

Uses

Azenosertib (ZN-c3) is a selective, orally active inhibitor for Wee1 inhibitor (IC50=3.9 nM). Azenosertib exhibits antitumor activity[1].

in vivo

Azenosertib (80 mg/kg; p.o.; 28 days) inhibits tumor growth in A427 xenograft NOD/SCID mice model[1].
Azenosertib (10 mg/kg, p.o.) shows plasma exposure Cmax of 2.1 μM, a half-time T1/2 of 2.3 h, an AUC0-24 h of 9.7 μM·h, and an oralbioavailability of F=142% in beagle dog model[1].

Animal Model:A427 xenograft NOD/SCID mice model[1]
Dosage:80 mg/kg
Administration:p.o. for 28 days
Result:Inhibited tumor growth.

References

[1] Huang PQ, et al. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer [published online ahead of print, 2021 Aug 23]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01121. DOI:10.1021/acs.jmedchem.1c01121

ZN-c3 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZN-c3 Suppliers

China 52 United States 1 Global 53
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
Shanghai XinKai Chemical Technology Co., Ltd.
Tel
021-58930698 15921516558
Fax
86-021-58933679
Email
zhangyichao84@126.com
Country
China
ProdList
961
Advantage
55
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1150
Advantage
64
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4790
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39999
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
Shanghai Biolang biotechnology Co.,Ltd
Tel
17764003753
Fax
13669031409
Email
2326587775@qq.com
Country
China
ProdList
188
Advantage
55
Shanghai Biolang biotechnology Co.,Ltd
Tel
17764003753
Fax
13669031409
Email
2326587775@qq.com
Country
China
ProdList
188
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60

2376146-48-2, ZN-c3Related Search:


  • 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1-[(7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta[b]pyridin-2-yl]-1,2-dihydro-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-
  • azenosertib
  • Zn-C3
  • ZNc3,ZN c3
  • 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1-[(7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta[b]pyridin-2-yl]-1,2-dihydro-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)- (ACI)
  • 1-[(7R)-7-ethyl-7-hydroxy-5,6-dihydrocyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one
  • Azenosertib (Zn-C3)
  • (R)-2-Allyl-1-(7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
  • ZN-c3, 10 mM in DMSO
  • 2376146-48-2