ChemicalBook > CAS DataBase List > D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)
- Product Name
- D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)
- CAS No.
- 2647442-13-3
- Chemical Name
- D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate)
- Synonyms
- GS-621763;VV116 (non-deuterated);GS-621763, 10 mM in DMSO;SARS-CoV,GS-621763,GS 621763,Inhibitor,SARS coronavirus,inhibit,GS621763;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate);(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate);(2R,3R,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-bis(2-methylpropanoyloxy)tetrahydrofuran-2-yl]methyl 2-methylpropanoate
- CBNumber
- CB79752006
- Molecular Formula
- C24H31N5O7
- Formula Weight
- 501.53
- MOL File
- 2647442-13-3.mol
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D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate) Property
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, away from moisture and light
- solubility
- DMSO: 2mg/mL, clear
- form
- Solid
- pka
- 4.11±0.30(Predicted)
- color
- White to off-white
- InChIKey
- RVSSLHFYCSUAHY-BSVPRABPNA-N
- SMILES
- C([C@@]1(C2=CC=C3C(=NC=NN23)N)O[C@H](COC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H]1OC(=O)C(C)C)#N |&1:1,13,21,28,r|
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML3571
- Product name
- GS-621763
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $175.75
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML3571
- Product name
- GS-621763
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $741
- Updated
- 2025/07/31
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D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate) Chemical Properties,Usage,Production
Uses
GS-621763 is an orally available precursor to GS-441524 that exhibits anti-SARS-CoV-2 viral activity in mice. GS-621763 reduces viral load to undetectable levels in ferrets infected with SARS-CoV-2[1][2].
Biological Activity
GS-621763 is an orally bioavailable analog of remdesivir, which is efficiently converted in plasma to active metabolite GS-441524, or in lungs to the bioactive triphosphate GS-443902. GS-621763 effectively reduces SARS-CoV-2 burden to near-undetectable levels in ferrets.
in vivo
GS-621763 (30 and 60 mg/kg p.o., twice daily for 4 days) shows potent antiviral activity in SARS-CoV-2 infected BALB/c mouse model[1]. GS-621763 (10 mg/kg, p.o., twice daily for 4 days) shows significant antiviral activity in SARS-CoV-2-infected ferret model[2].
| Animal Model: | SARS-CoV-2 infected BALB/c mouse model[1] |
| Dosage: | 30 mg/kg and 60 mg/kg |
| Administration: | Oral gavage (p.o.), twice daily for 4 days |
| Result: | Significantly reduced lung infectious virus levels (30 mg/kg); Further reduced ung infectious virus levels (60 mg/kg). |
| Animal Model: | SARS-CoV-2-infected ferret model[2] |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage (p.o.), twice daily for 4 days |
| Result: | Significantly reduced SARS-CoV-2 shedding, with virus undetectable in nasal lavages. |
References
[1] Sch?fer A, et al. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111. DOI:10.1101/2021.09.13.460111
[2] Cox RM, et al. Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets. Nat Commun. 2021 Nov 5;12(1):6415. DOI:10.1038/s41467-021-26760-4
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 3,4,6-tris(2-methylpropanoate) Preparation Products And Raw materials
Raw materials
Preparation Products
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