GPI choline
- Product Name
- GPI choline
- CAS No.
- 425642-32-6
- Chemical Name
- GPI choline
- Synonyms
- Plain;GPI choline;PuriActives GPI;Glycerophosphoinositol choline;D-myo-Inositol, 1-[(2R)-2,3-dihydroxypropyl hydrogen phosphate], ion(1-), 2-hydroxy-N,N,N-trimethylethanaminium (1:1)
- CBNumber
- CB79879707
- Molecular Formula
- C14H32NO12P
- Formula Weight
- 437.38
- MOL File
- 425642-32-6.mol
GPI choline Property
- Cosmetics Ingredients Functions
- SKIN PROTECTING
- InChIKey
- PTZZCYHESHNXFL-MFJCNYFVNA-M
- SMILES
- C(CO)[N+](C)(C)C.O([C@@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](O)[C@H]1O)O)P([O-])(=O)OC[C@H](O)CO |&1:8,9,10,12,14,16,24,r|
N-Bromosuccinimide Price
- Product number
- HY-B1337B
- Product name
- Glycerophosphoinositol choline
- Purity
- 98.0%
- Packaging
- 5mg
- Price
- $737
- Updated
- 2026/05/26
- Product number
- HY-B1337B
- Product name
- Glycerophosphoinositol choline
- Purity
- 98.0%
- Packaging
- 10mg
- Price
- $1188
- Updated
- 2026/05/26
GPI choline Chemical Properties,Usage,Production
Uses
Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2].
in vivo
Glycerophosphoinositol choline (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice[2].
| Animal Model: | Postoperative pain model of female C57/Bl6 mice[2] |
| Dosage: | 0.2 and 100 mg/kg/h |
| Administration: | Subcutaneous injection, 24 or 48 hours |
| Result: | Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h. Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours. |
IC 50
Human Endogenous Metabolite
References
[1] M Q Holmes-McNary, et al. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):9-16. DOI:10.1016/s0165-3806(97)00044-8
[2] T J Rowley, et al. Antinociceptive and anti-inflammatory effects of choline in a mouse model of postoperative pain. Br J Anaesth. 2010 Aug;105(2):201-7. DOI:10.1093/bja/aeq113
GPI choline Preparation Products And Raw materials
Raw materials
Preparation Products
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