GPI choline

Product Name: GPI choline
CAS No.: 425642-32-6
Chemical Name: GPI choline
Synonyms: Plain;GPI choline;PuriActives GPI;Glycerophosphoinositol choline;D-myo-Inositol, 1-[(2R)-2,3-dihydroxypropyl hydrogen phosphate], ion(1-), 2-hydroxy-N,N,N-trimethylethanaminium (1:1)
CBNumber: CB79879707
Molecular Formula: C14H32NO12P
Formula Weight: 437.38
MOL File: 425642-32-6.mol

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Hazard and Precautionary Statements (GHS)

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GPI choline Chemical Properties,Usage,Production

Uses

Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2].

in vivo

Glycerophosphoinositol choline (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice^[2].

Animal Model:	Postoperative pain model of female C57/Bl6 mice^[2]
Dosage:	0.2 and 100 mg/kg/h
Administration:	Subcutaneous injection, 24 or 48 hours
Result:	Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED₅₀ value of choline dose was 1.7 mg/kg/h. Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED₅₀ value of 4.7 mg/kg/h but not 24 hours.

IC 50

Human Endogenous Metabolite

References

[1] M Q Holmes-McNary, et al. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):9-16. DOI:10.1016/s0165-3806(97)00044-8
[2] T J Rowley, et al. Antinociceptive and anti-inflammatory effects of choline in a mouse model of postoperative pain. Br J Anaesth. 2010 Aug;105(2):201-7. DOI:10.1093/bja/aeq113

GPI choline Preparation Products And Raw materials

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GPI choline Suppliers

China 9 United States 1 Global 10

Hangzhou J&H Chemical Co., Ltd.

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Puripharm Co., Ltd.

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Jinan ponder chemical co. LTD

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Shaanxi Dideu Medichem Co. Ltd

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425642-32-6, GPI cholineRelated Search:

glycerol dihydrogen phosphate, sodium salt Pro-xylane β-Nicotinamide Mononucleotide Glycerophosphoinositol 3,4,5-trphosphate Inositol

D-myo-Inositol, 1-[(2R)-2,3-dihydroxypropyl hydrogen phosphate], ion(1-), 2-hydroxy-N,N,N-trimethylethanaminium (1:1)

Glycerophosphoinositol choline

GPI choline

Plain

PuriActives GPI

425642-32-6

C14H32NO12P