ChemicalBook > CAS DataBase List > Vasonatrin Peptide (VNP)

Vasonatrin Peptide (VNP)

Product Name: Vasonatrin Peptide (VNP)
CAS No.: 141676-35-9
Chemical Name: Vasonatrin Peptide (VNP)
Synonyms: Vasonatrin Peptide (VNP);Vasonatrin Peptide (VNP) Trifluoroacetate;H-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH;GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR ((DISULFIDE BRIDGE: CYS6-CYS22);L-Tyrosine, glycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-, cyclic (6→22)-disulfide
CBNumber: CB7998982
Molecular Formula: C124H198N36O36S3
Formula Weight: 2865.34
MOL File: 141676-35-9.mol

Less

Vasonatrin Peptide (VNP) Property

Density: 1.47±0.1 g/cm3(Predicted)
Sequence: Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys6-Cys22)

Less

Hazard and Precautionary Statements (GHS)

Less

Vasonatrin Peptide (VNP) Chemical Properties,Usage,Production

Uses

Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway[1][2][3].

in vivo

Vasonatrin peptide (100 μg/kg; i.v. ; 10 min before reperfusion) attenuates myocardial ischemia-reperfusion injury in diabetic rats^[3].

Animal Model:	High-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats^[3]
Dosage:	100 μg/kg
Administration:	I.v. ; 10 min before reperfusion
Result:	Significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/d_tmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Inhibited endoplasmic reticulum (ER) stress by suppressing glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP).

References

[1] Wei CM, et al. Vasonatrin peptide: a unique synthetic natriuretic and vasorelaxing peptide. J Clin Invest. 1993;92(4):2048-2052. DOI:10.1172/JCI116800
[2] Chen BY, et al. Vasonatrin peptide, a new regulator of adiponectin and interleukin-6 production in adipocytes. J Endocrinol Invest. 2011;34(10):742-746. DOI:10.3275/7727
[3] Shi Z, et al. Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms. Am J Physiol Heart Circ Physiol. 2015;308(4):H281-H290. DOI:10.1152/ajpheart.00666.2014

Vasonatrin Peptide (VNP) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Vasonatrin Peptide (VNP) Suppliers

China 43 United States 5 Global 48

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1010
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4802
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 0571-88211921
Email: sales1@gotopbio.com
Country: CHINA
ProdList: 2609
Advantage: 58

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 995
Advantage: 58

Nanjing TGpeptide Biotechnology Co.,Ltd.

Tel: 18115476705
Email: sales@tgpeptide.com
Country: China
ProdList: 3058
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 15397062932
Email: sales1@gotopbio.com
Country: China
ProdList: 2923
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Chengdu Jinglin Biotechnology Co., Ltd.

Tel: 17711399154
Email: 3211919385@qq.com
Country: China
ProdList: 1815
Advantage: 58

Shaoxing Junyu Biotechnology Co., LTD

Tel: 0571-0571-88211921 19105816207
Email: sales4@gotopbio.com
Country: China
ProdList: 5144
Advantage: 58

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 6979
Advantage: 58

Hangzhou Baige Pharmaceutical Technology Co. , Ltd.

Tel: 0571-85350119 15888826472
Email: 15888826472@163.com
Country: China
ProdList: 2729
Advantage: 58

Shanghai HongTide Biotechnology Co.,Ltd.

Tel: 15318089928
Email: alex@hanhonggroup.com
Country: China
ProdList: 4604
Advantage: 58

Combio (Suzhou) Ltd.

Tel: 17751201929
Email: office@combiosz.com
Country: China
ProdList: 3000
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Zhejiang Jiekun Biotechnology Co., Ltd

Tel: 0571-88211951 13735575465
Email: sales1@gotopbio.com
Country: China
ProdList: 4880
Advantage: 58

Taiyuan Bailihengkang Biotechnology Co., Ltd

Tel: 19135651983
Email: 18611134419@163.com
Country: China
ProdList: 4416
Advantage: 58

Hangzhou Beiputai Biopharmaceutical Co., Ltd

Tel: 0571-85350119 15888826472
Email: bptsales@163.com
Country: China
ProdList: 3834
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-029-81148929 17791530722
Email: 1049@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Nanjing Typeptide Biotechnology Co.,Ltd.

Tel: 19941518170
Email: sales@typeptide.com
Country: China
ProdList: 3920
Advantage: 58

Changsha MOL Changes Biotechnology Co., Ltd.

Tel: +8619375158599
Email: info@molchanges.com
Country: China
ProdList: 5218
Advantage: 58

Shenzhen Nexconn Pharmatechs Ltd

Tel: +86-755-89396905 +86-15013857715
Email: admin@nexconn.com
Country: China
ProdList: 10405
Advantage: 58

Nanjing TGpeptide

Tel: +86-13347807150
Email: support@tgpeptide.com
Country: China
ProdList: 3279
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Shanghai Qiangyao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: caiwuchinapeptides@126.com
Country: CHINA
ProdList: 1253
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6906
Advantage: 58

asiapeptide

Tel: --
Fax: --
Email: frog5235@peptide-search.com
Country: China
ProdList: 1367
Advantage: 58

Guangzhou Ruiboao Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@raybiotech.com
Country: CHINA
ProdList: 2408
Advantage: 58

Beijing Chief-East Tech Co.,Ltd (Qwbio)

Tel: --
Fax: --
Email: info@qwbio.com
Country: China
ProdList: 6912
Advantage: 50

Shenzhen Haodi Huatuo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: lm0210@otwobiotech.com
Country: CHINA
ProdList: 6757
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6757
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6170
Advantage: 58

Shanghai Hanhong Chemical Co., Ltd

Tel: --
Fax: --
Email: info@hanhonggroup.com
Country: China
ProdList: 3944
Advantage: 67

Advanced Technology & Industrial Co., Ltd.

Tel: --
Fax: --
Email: sales@advtechind.com
Country: China
ProdList: 6523
Advantage: 75

141676-35-9, Vasonatrin Peptide (VNP) Related Search:

Vasopressin CEDAEVFKDSMVPGEK VAPREOTIDE ACETATE Arginine Vasopressin-d5 CYS-TYR-ILE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 Vasoactive Intestinal Peptide Vasopressin CYS-TYR-ILE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 ACETATE SALT VASONATRIN PEPTIDE HIV-2 Peptide

Vasonatrin Peptide (VNP)

GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR ((DISULFIDE BRIDGE: CYS6-CYS22)

H-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH

L-Tyrosine, glycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-, cyclic (6→22)-disulfide

Vasonatrin Peptide (VNP) Trifluoroacetate

141676-35-9

C124H198N36O36S3