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EPLIVANSERIN FUMARATE

Product Name
EPLIVANSERIN FUMARATE
CAS No.
130580-02-8
Chemical Name
EPLIVANSERIN FUMARATE
Synonyms
SR 46349B;SR-46349 Fumarate;EPLIVANSERIN FUMARATE;SR-46349 hemifumarate;Eplivanserin hemifumarate;SR-46349 hemifumarate salt;Eplivanserin hemifumarate salt;SR-46349 hemifumarate salt >=98% (HPLC);TRANS-2''-FLUORO-4-HYDROXYCHALCONE O-[(Z)-2-(DIMETHYLAMINO)ETHYL]OXIME--FUMARIC ACID (2:1);4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate salt
CBNumber
CB81011733
Molecular Formula
C23H25FN2O6
Formula Weight
444.46
MOL File
130580-02-8.mol
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EPLIVANSERIN FUMARATE Property

storage temp. 
2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
color 
white to off-white
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7201
Product name
SR-46349 hemifumarate salt
Purity
≥98% (HPLC)
Packaging
5mg
Price
$103
Updated
2025/07/31
Sigma-Aldrich
Product number
S7201
Product name
SR-46349 hemifumarate salt
Purity
≥98% (HPLC)
Packaging
25mg
Price
$399
Updated
2025/07/31
Tocris
Product number
4958
Product name
Eplivanserinhemifumarate
Purity
≥98%(HPLC)
Packaging
10
Price
$164
Updated
2021/12/16
Tocris
Product number
4958
Product name
Eplivanserinhemifumarate
Purity
≥98%(HPLC)
Packaging
50
Price
$690
Updated
2021/12/16
Usbiological
Product number
255254
Product name
Eplivanserin hemifumarate
Packaging
10mg
Price
$418
Updated
2021/12/16
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EPLIVANSERIN FUMARATE Chemical Properties,Usage,Production

Uses

Eplivanserin Hemifumarate is a 5-HT2A antagonist.

Biological Activity

SR-46349 is an antagonist of 5-HT (2A/2C) receptor and increases the release of dopamine by medial prefrontal cortex in rats.1 It increases the signal transduction induced by 5-HT2 receptor by binding with high affinity.2 SR-46349 inhibits the aggregation of rabbit and human platelets in response to serotonin.3', 'ASTAR (Antagonist of Serotonin 5HT2A Receptors).

in vivo

Eplivanserin hemifumarate (SR 46349B) inhibits 5-HT2 receptor binding of [3H]ketanserin with an ED50 of 0.087 mg/kg after i.p. injection, and 0.097 mg/kg after p.o administration in mice[1].
SR 46349B (0.25-1 mg/kg; i.p.) blocks Cocaine-evoked hyperactivity following repeated Cocaine treatment in rats[2].

IC 50

5-HT2A Receptor: 5.8 nM (IC50); 5-HT2C Receptor: 120 nM (IC50)

storage

Store at +4°C

EPLIVANSERIN FUMARATE Preparation Products And Raw materials

Raw materials

Preparation Products

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EPLIVANSERIN FUMARATE Suppliers

China 17 South Korea 1 The Netherlands 1 United Kingdom 1 United States 6 Global 26
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30

130580-02-8, EPLIVANSERIN FUMARATERelated Search:

4-PHENYLBUT-3-EN-2-ONE OXIME Eplivanserin EPLIVANSERIN FUMARATE

  • EPLIVANSERIN FUMARATE
  • SR 46349B
  • TRANS-2''-FLUORO-4-HYDROXYCHALCONE O-[(Z)-2-(DIMETHYLAMINO)ETHYL]OXIME--FUMARIC ACID (2:1)
  • (Z,E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime fumarate (2:1)
  • Eplivanserin hemifumarate
  • 4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate salt
  • Eplivanserin hemifumarate salt
  • SR-46349 hemifumarate salt
  • (1Z,2E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime hemifumarate
  • SR-46349 hemifumarate salt >=98% (HPLC)
  • SR-46349 Fumarate
  • SR-46349 hemifumarate
  • 130580-02-8
  • 2C19H21FN2O2C4H4O4
  • C42H46F2N4O8