4-Chloro-3-methoxy-2-methylpyridine
- Product Name
- 4-Chloro-3-methoxy-2-methylpyridine
- CAS No.
- 107512-34-5
- Chemical Name
- 4-Chloro-3-methoxy-2-methylpyridine
- Synonyms
- Pantoprazole Impurity 23;4-Chloro-3-methoxy-2-methylpyridine;Pyridine, 4-chloro-3-methoxy-2-methyl-
- CBNumber
- CB81016879
- Molecular Formula
- C7H8ClNO
- Formula Weight
- 157.6
- MOL File
- 107512-34-5.mol
4-Chloro-3-methoxy-2-methylpyridine Property
- Boiling point:
- 206.1±35.0 °C(Predicted)
- Density
- 1.168±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 5.45±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381020
- Product name
- 4-Chloro-3-methoxy-2-methylpyridine
- Packaging
- 5000mg
- Price
- $1240
- Updated
- 2021/12/16
- Product number
- 4H07-5-20
- Product name
- 4-Chloro-3-methoxy-2-methylpyridine
- Packaging
- 5G
- Price
- $1250
- Updated
- 2021/12/16
- Product number
- 113316
- Product name
- 4-Chloro-3-methoxy-2-methylpyridine
- Packaging
- 5g
- Price
- $1300
- Updated
- 2021/12/16
- Product number
- FC134566
- Product name
- 4-Chloro-3-methoxy-2-methylpyridine
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4H07-5-20
- Product name
- 4-Chloro-3-methoxy-2-methylpyridine
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
4-Chloro-3-methoxy-2-methylpyridine Chemical Properties,Usage,Production
Uses
4-Chloro-3-methoxy-2-methylpyridine is a useful synthetic compound
Synthesis
76015-11-7
107512-34-5
General procedure for the synthesis of 4-chloro-3-methoxy-2-methylpyridin-4-one from 3-methoxy-2-methyl-1H-pyridin-4-one: 3-methoxy-2-methyl-4(1H)-pyridinone (27.8 g, 0.2 mol) was added to phosphorus trichloride (200 mL), and the mixture was heated and refluxed for 18 hr at 90°C under nitrogen protection. Upon completion of the reaction, the homogeneous mixture was cooled to 20°C and subsequently concentrated under reduced pressure. The concentrated residue was dissolved in ice water and the pH was adjusted to 12 with 40% sodium hydroxide solution, at which point a turbid suspension appeared. Extraction was carried out with dichloromethane (3 x 100 mL) and the organic phases were combined and washed with water. The organic phase was dried over anhydrous magnesium sulfate and the dichloromethane was removed by rotary evaporation to afford the target product 4-chloro-3-methoxy-2-methylpyridine (30.2 g, 96% yield). The product was characterized by 1H NMR (CDCl3): δ 8.14 (d, 1H, J = 5.32 Hz), 7.17 (d, 1H, J = 5.10 Hz), 3.85 (s, 3H), 2.54 (s, 3H). The mass spectrum (ESI) showed a m/z of 157.91 ([M+H]+).
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 6, p. 1049 - 1057
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 9, p. 2808 - 2811
[3] Patent: CN103483248, 2016, B. Location in patent: Paragraph 0034; 0035
[4] Journal of Medicinal Chemistry, 1995, vol. 38, # 25, p. 4906 - 4916
[5] Patent: US4738975, 1988, A
4-Chloro-3-methoxy-2-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-3-methoxy-2-methylpyridine manufacturers
- Product
- 4-Chloro-3-methoxy-2-methylpyridine 107512-34-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-06