1-AMINO-2-METHYLNAPHTHALENE

Product Name: 1-AMINO-2-METHYLNAPHTHALENE
CAS No.: 2246-44-8
Chemical Name: 1-AMINO-2-METHYLNAPHTHALENE
Synonyms: 2-Methylnaphthalen-1-amine;2-METHYLNAPHTHYLAMINE;2-methyl-1-naftylamin;2-methyl-1-naphthylamin;2-Methyl-1-naphtylamine;2-METHYL-1-NAPHTHYLAMINE;1-Amino-2-methylphthalene;2-METHYL-1-NAPHTHALENAMINE;1-Amino-2-methylnaphtalene;1-AMINO-2-METHYLNAPHTHALENE
CBNumber: CB8103602
Molecular Formula: C11H11N
Formula Weight: 157.21
MOL File: 2246-44-8.mol

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1-AMINO-2-METHYLNAPHTHALENE Property

Melting point:: 28-31 °C(lit.)
Boiling point:: 165 °C
Density: 1.67
refractive index: n20/D 1.670
Flash point:: 28 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: powder to lump to clear liquid
pka: 4.78±0.10(Predicted)
color: White or Colorless to Brown
BRN: 2042530
Stability:: Light Sensitive
InChI: InChI=1S/C11H11N/c1-8-6-7-9-4-2-3-5-10(9)11(8)12/h2-7H,12H2,1H3
InChIKey: JMBLSGAXSMOKPN-UHFFFAOYSA-N
SMILES: C1(N)=C2C(C=CC=C2)=CC=C1C
CAS DataBase Reference: 2246-44-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 26-36
WGK Germany: 3
RTECS: QM3675000
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 67960
Product name: 2-Methyl-1-naphthylamine
Purity: ≥98.0% (GC)
Packaging: 10ml
Price: $536
Updated: 2025/07/31

TCI Chemical

Product number: A0917
Product name: 1-Amino-2-methylnaphthalene
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $90
Updated: 2025/07/31

TCI Chemical

Product number: A0917
Product name: 1-Amino-2-methylnaphthalene
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $305
Updated: 2025/07/31

TRC

Product number: A577025
Product name: 1-Amino-2-Methylnaphthalene
Packaging: 5g
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: 1343AB
Product name: 1-Amino-2-methylnaphthalene
Packaging: 5g
Price: $144
Updated: 2021/12/16

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1-AMINO-2-METHYLNAPHTHALENE Chemical Properties,Usage,Production

Uses

1-Amino-2-Methylnaphthalene is used in preparation of (Piperazinyl)pyridopyrimidinone derivatives as KRAS G12C inhibitor for treatment of KRAS G12C-related diseases.

Synthesis

2586-62-1

2246-44-8

General procedure for the synthesis of 1-bromo-2-methylnaphthalene from 1-bromo-2-methylnaphthalene: In an oven-dried vial (35x12 mm) fitted with a PTFE-sealed screw cap, a magnetic stir bar, ((+/-)-binap)Ni[P(OPh)3]2-2PhCH3 (39 mg, 25 μmol, 5 mol%), (+/-)- binap (15 mg, 25 μmol, 5 mol%) and the corresponding aryl halide (0.50 mmol, 1.0 equiv). Subsequently, the vial was transferred to an argon-filled glove box and NaOtBu (216 mg, 2.20 mmol, 4.40 eq.) and NH3 (0.5 M solution of 1,4-dioxane, 3.0 mL, 1.5 mmol, 3.0 eq.) were added sequentially. After sealing the reaction vial, it was removed from the glove box and placed in an oil bath preheated to 120 °C with stirring for 18 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with Et2O (15 mL) and washed sequentially with 1 M NaOH (10 mL) and H2O (10 mL). The organic layer was adsorbed on silica gel and purified by fast column chromatography (eluent: EtOAc/hexane or EtOAc/MeOH) to obtain the target product aniline analogs. Specifically for the synthesis of 2-methylnaphthalen-1-amine (19k), 1-bromo-2-methylnaphthalene (84 μL, 0.50 mmol) was used as the starting material according to the general method described above and purified by fast column chromatography (eluent: Hexane/EtOAc 90:10) to afford the dark orange oily target compound 19k (73 mg, 0.46 mmol, 93% yield). The spectral data were in agreement with those reported in the literature [64]: Rf 0.20 (hexane/EtOAc 90:10); 1H NMR (CDCl3, 500 MHz) δ 7.85-7.80 (2H, m, 2Ar-H), 7.50-7.43 (2H, m, 2Ar-H), 7.33 (1H, d, J = 8.3 Hz, Ar-H), 7.28 (1H, d, J = 8.3 Hz, Ar-H), 4.11 (2H, br s, NH2), 2.38 (3H, s, CH3); 13C NMR (CDCl3, 125 MHz) δ 139.0 (Ar-C), 133.2 (Ar-C), 129.4 (Ar-CH), 128.6 (Ar-CH), 124.92 (Ar-CH), 124.92 (Ar-CH), 128.6 (Ar-CH), 124.92 (Ar-CH), 128.6 (Ar-CH), 128.6 (Ar-CH), 128.6 (Ar-CH), 124.9 (Ar-CH) 124.92 (Ar-CH), 124.87 (Ar-CH), 123.4 (Ar-C), 120.3 (Ar-CH), 118.3 (Ar-CH), 116.3 (Ar-CH), 17.8 (CH3).

References

[1] Australian Journal of Chemistry, 2015, vol. 68, # 12, p. 1842 - 1853
[2] Journal of Organic Chemistry, 2010, vol. 75, # 14, p. 4887 - 4890

1-AMINO-2-METHYLNAPHTHALENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-AMINO-2-METHYLNAPHTHALENE Suppliers

Americas 1 China 132 Europe 1 France 1 Germany 2 India 3 Japan 1 Norway 1 Switzerland 2 United Kingdom 7 United States 12 Global 163

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View Lastest Price from 1-AMINO-2-METHYLNAPHTHALENE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-AMINO-2-METHYLNAPHTHALENE 2246-44-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-11

Career Henan Chemical Co

Product: 2-Methyl-1-naphthalenamine 2246-44-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-30

2246-44-8, 1-AMINO-2-METHYLNAPHTHALENERelated Search:

3-Hydroxy-1,2,3,4-tetrahydrobenzo[h]quinoline 1-AMINO-2-METHYLNAPHTHALENE HYDROCHLORIDE 1-AMINO-2-METHYLNAPHTHALENE 2,3,3-Trimethyl-3H-benzo[g]indole 2-METHYL-1-NITRONAPHTHALENE 3,3'-DIMETHYLNAPHTHIDINE 1-AMINO-2-METHYLNAPHTHALENE HYDROCHLORIDE 98+% 2-Methylnaphthalene Methylnaphthalene DIHYDROSANGUINARINE 2-(DIMETHYLAMINO)VINYL-1-NITRONAPHTHALENE 2-(1-NITRO-2-NAPHTHYL)ACETALDEHYDE OXIME 1-(4-CHLOROPHENYL)-4-(1-NITRO-2-NAPHTHYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE 2-(1-NITRO-2-NAPHTHYL)ACETALDEHYDE O-METHYLOXIME 4-METHYL-N-[2-(1-NITRO-2-NAPHTHYL)VINYL]ANILINE 2-(1-NITRO-2-NAPHTHYL)ACETONITRILE AURORA KA-3350 4-(1-NITRO-2-NAPHTHYL)-1-(3-NITROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE

2-methyl-1-naftylamin

2-methyl-1-naphthylamin

1-AMINO-2-METHYLNAPHTHALENE

2-METHYL-1-NAPHTHALENAMINE

2-METHYL-1-NAPHTHYLAMINE

2-METHYLNAPHTHYLAMINE

1-AMINO-2-METHYLNAPHTHALENE 97+%

2-Methyl-1-aminonaphthalene

2-Methyl-1-naphtylamine

2-Methylnaphthalen-1-amine

1-NaphthalenaMine, 2-Methyl-

1-Amino-2-methylnaphtalene

1-Amino-2-methylnaphthalene &gt

1-AMINO-2-METHYLNAPHTHALENE ISO 9001：2015 REACH

1-Amino-2-methylphthalene

2246-44-8

C11 to C37

Amines

Building Blocks

Nitrogen Compounds

Organic Building Blocks

1