Benzonitrile, 4-formyl-3-hydroxy-

Product Name: Benzonitrile, 4-formyl-3-hydroxy-
CAS No.: 84102-89-6
Chemical Name: Benzonitrile, 4-formyl-3-hydroxy-
Synonyms: 4-Formyl-3-hydroxybenzonitrile;Mesalazine Impurity 43;Finelidone impurity 55;4-Formyl-3-hydroxybenzonitril;Benzonitrile, 4-formyl-3-hydroxy-;4-Formyl-3-hydroxybenzonitrile 95+%;Benzonitrile, 4-formyl-3-hydroxy- (9CI);5-Cyano-2-formylphenol, 4-Cyano-2-hydroxybenzaldehyde
CBNumber: CB81040821
Molecular Formula: C8H5NO2
Formula Weight: 147.13
MOL File: 84102-89-6.mol

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Benzonitrile, 4-formyl-3-hydroxy- Property

Boiling point:: 288.7±30.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: 2-8°C, stored under nitrogen
pka: 6.79±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: F754665
Product name: 4-Formyl-3-hydroxybenzonitrile
Packaging: 50mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC41214
Product name: 4-Cyano-2-hydroxybenzaldehyde
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC41214
Product name: 4-Cyano-2-hydroxybenzaldehyde
Packaging: 250mg
Price: $150
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4637-1-M6
Product name: 4-Formyl-3-hydroxybenzonitrile
Purity: 95.0%
Packaging: 250mg
Price: $218
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0377617
Product name: 4-FORMYL-3-HYDROXY BENZONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $497.79
Updated: 2021/12/16

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Benzonitrile, 4-formyl-3-hydroxy- Chemical Properties,Usage,Production

Synthesis

21962-45-8

84102-89-6

Example 24A Synthesis of 4-formyl-3-hydroxybenzonitrile: 100 mL of a dichloromethane solution of boron tribromide (1M, 100 mmol) was slowly added dropwise to 80 mL of anhydrous dichloromethane solution containing 8 g (49.64 mmol) of 4-formyl-3-methoxybenzonitrile, protected by argon gas and at -78 °C. The reaction mixture was stirred continuously at room temperature until complete reaction of the raw material was confirmed by TLC detection (about 5 days). Subsequently, the reaction system was cooled to 0 °C and minimally neutralized with saturated sodium bicarbonate solution. The organic and aqueous phases were separated and the organic phase was further washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography using cyclohexane/ethyl acetate (3:1, v/v) as mobile phase. Finally, 4.5 g of the target product 3-hydroxy-4-formylbenzonitrile in yellow solid form was obtained in 61% yield. The product was analyzed by LC-MS (Method 1) showing Rt = 1.38 min; [MH]- = 146. 1H-NMR (300 MHz, CDCl3) data were as follows: δ = 7.38 (d, 1H), 7.38 (s, 1H), 7.77 (d, 1H), 10.33 (s, 1H), 11.38 (s, 1H).

References

[1] Patent: US2010/305052, 2010, A1. Location in patent: Page/Page column 20-21
[2] Patent: KR101614164, 2016, B1. Location in patent: Paragraph 0328-0331
[3] Patent: US2010/136142, 2010, A1

Benzonitrile, 4-formyl-3-hydroxy- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzonitrile, 4-formyl-3-hydroxy- Suppliers

China 78 Europe 1 Germany 1 India 2 United Kingdom 2 United States 13 Global 97

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View Lastest Price from Benzonitrile, 4-formyl-3-hydroxy- manufacturers

Career Henan Chemical Co

Product: Benzonitrile, 4-formyl-3-hydroxy- 84102-89-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-14

84102-89-6, Benzonitrile, 4-formyl-3-hydroxy-Related Search:

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Benzonitrile, 4-formyl-3-hydroxy-

Benzonitrile, 4-formyl-3-hydroxy- (9CI)

4-Formyl-3-hydroxybenzonitril

4-Formyl-3-hydroxybenzonitrile

5-Cyano-2-formylphenol, 4-Cyano-2-hydroxybenzaldehyde

4-Formyl-3-hydroxybenzonitrile 95+%

Finelidone impurity 55

Mesalazine Impurity 43

84102-89-6

Aromatic

ALDEHYDE

Drug Intermediates