ChemicalBook > CAS DataBase List > Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI)

Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI)

Product Name
Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI)
CAS No.
67434-65-5
Chemical Name
Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI)
Synonyms
4-CHLORO-5,6-DIMETHYLPYRIMIDINE;Pyrimidine, 4-chloro-5,6-dimethyl-;Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI);4-chloro-5,6-dimethylpyrimidine(SALTDATA: FREE)
CBNumber
CB81047279
Molecular Formula
C6H7ClN2
Formula Weight
142.59
MOL File
67434-65-5.mol
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Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI) Property

Melting point:
215-216 °C
Boiling point:
80-82 °C(Press: 10 Torr)
Density 
1.184±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
1.12±0.26(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T776210
Product name
4-chloro-5,6-dimethylpyrimidine
Packaging
250mg
Price
$240
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC153913
Product name
4-chloro-5,6-dimethylpyrimidine
Packaging
500mg
Price
$290
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-PA
Product name
4-Chloro-5,6-dimethylpyrimidine
Purity
95%
Packaging
250mg
Price
$360
Updated
2021/12/16
AK Scientific
Product number
6139AJ
Product name
4-Chloro-5,6-dimethylpyrimidine
Packaging
1g
Price
$155
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC153913
Product name
4-chloro-5,6-dimethylpyrimidine
Packaging
250mg
Price
$165
Updated
2021/12/16
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Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI) Chemical Properties,Usage,Production

Synthesis

4316-97-6

13061-96-6

67434-65-5

GENERAL STEPS: 4,6-Dichloro-5-methylpyrimidine (Sigma-Aldrich, item 595446, 0.50 g, 3.07 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.18 g, 0.15 mmol) were dissolved in toluene (6 mL). Cesium carbonate (3 g, 9.20 mmol) was added to the mixture, followed by methylboronic acid (0.20 g, 3.37 mmol) and N,N-dimethylformamide (DMF, 1 mL). The reaction mixture was placed in a microwave reactor and heated by microwave radiation at 140°C (2 cycles of 30 min each). Upon completion of the reaction, it was cooled to room temperature and filtered. The solvent was removed under reduced pressure and the residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and brine. The organic phase was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to afford the target product 4-chloro-5,6-dimethylpyrimidine (0.18 g, 1.26 mmol, 41% yield). The product was analyzed by ultra-performance liquid chromatography (UPLC) with a retention time (rt) of 0.53 min, and the major peaks observed were 143 ([M + 1-HCl], 100%) and 445 ([M + 1-HCl], 33%). The elemental analysis results were consistent with the theoretical calculated value (142) for C6H7ClN2.1H NMR (400 MHz, CDCl3) δ (ppm): 8.70 (s, 1H), 2.57 (s, 3H), 2.39 (s, 3H).

References

[1] Patent: WO2009/3997, 2009, A1. Location in patent: Page/Page column 20-21

Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI) Suppliers

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67434-65-5, Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI)Related Search:

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  • 4-CHLORO-5,6-DIMETHYLPYRIMIDINE
  • 4-chloro-5,6-dimethylpyrimidine(SALTDATA: FREE)
  • Pyrimidine, 4-chloro-5,6-dimethyl- (7CI,9CI)
  • Pyrimidine, 4-chloro-5,6-dimethyl-
  • 67434-65-5
  • PYRIMIDINE