Furo[2,3-c]pyridine-5-carboxaldehyde (9CI)
- Product Name
- Furo[2,3-c]pyridine-5-carboxaldehyde (9CI)
- CAS No.
- 478148-61-7
- Chemical Name
- Furo[2,3-c]pyridine-5-carboxaldehyde (9CI)
- Synonyms
- Furo[2,3-c]pyridine-5-carboxaldehyde;Furo[2,3-c]pyridine-5-carboxaldehyde (9CI)
- CBNumber
- CB81050112
- Molecular Formula
- C8H5NO2
- Formula Weight
- 147.13
- MOL File
- 478148-61-7.mol
Furo[2,3-c]pyridine-5-carboxaldehyde (9CI) Property
- Boiling point:
- 261.1±20.0 °C(Predicted)
- Density
- 1.322±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.70±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CHM0392683
- Product name
- FURO[2,3-C]PYRIDINE-5-CARBOXALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.95
- Updated
- 2021/12/16
- Product number
- W6444
- Product name
- Furo[2,3-c]pyridine-5-carboxaldehyde
- Packaging
- 1g
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- 126427
- Product name
- Furo[2,3-c]pyridine-5-carboxaldehyde
- Purity
- >95%
- Packaging
- 1g
- Price
- $1224
- Updated
- 2021/12/16
- Product number
- CD11118743
- Product name
- Furo[2,3-c]pyridine-5-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- CD11118743
- Product name
- Furo[2,3-c]pyridine-5-carboxaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $1426
- Updated
- 2021/12/16
Furo[2,3-c]pyridine-5-carboxaldehyde (9CI) Chemical Properties,Usage,Production
Synthesis
478148-60-6
478148-61-7
a-9) Preparation of furo[2,3-c]pyridine-5-carbaldehyde: Furo[2,3-c]pyridin-5-ylmethanol (521 mg, 3.49 mmol) was dissolved in acetone (17 mL), followed by the addition of 2,2,6,6-tetramethylpiperidin-1-yloxy (27 mg, 170 μmol). Under ice bath cooling conditions, 1,3,5-trichloro-2,4,6-triazinetrione (892 mg, 3.84 mmol) was slowly added to the reaction mixture and the reaction was stirred at the same temperature for 5 min. After completion of the reaction, the mixture was concentrated under reduced pressure, cooled to 0°C and then water and saturated aqueous sodium bicarbonate were added sequentially and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford furo[2,3-c]pyridine-5-carbaldehyde (488 mg, 95% yield) as a yellow solid.1H-NMR (CDCl3) δ: 6.98 (1H, dd, J = 0.8, 2.2 Hz), 7.88 (1H, d, J = 2.2 Hz), 8.32 ( 1H, d, J = 0.8 Hz), 9.03 (1H, s), 10.18 (1H, s).
References
[1] Patent: US2010/280013, 2010, A1. Location in patent: Page/Page column 53
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4425 - 4436
[3] Patent: WO2004/52894, 2004, A1. Location in patent: Page 35
Furo[2,3-c]pyridine-5-carboxaldehyde (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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