1-(5-aMino-2-fluorophenyl)ethanone

Product Name: 1-(5-aMino-2-fluorophenyl)ethanone
CAS No.: 67500-19-0
Chemical Name: 1-(5-aMino-2-fluorophenyl)ethanone
Synonyms: 1-(5-Amino-2-fluorophenyl);5'-Amino-2'-fluoroecetophenone;5'-Amino-2'-fluoroacetophenone;5'-Amino-2'-fluoroacetophenone 95%;1-(5-AMINO-2-FLUOROPHENYL)ETHANONE;Ethanone, 1-(5-aMino-2-fluorophenyl)-;Ethanone, 1-(5-amino-2-fluorophenyl)- (9CI);1-(5-Amino-2-fluorophenyl)ethan-1-one, 3-Acetyl-4-fluoroaniline
CBNumber: CB81064249
Molecular Formula: C8H8FNO
Formula Weight: 153.15
MOL File: 67500-19-0.mol

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1-(5-aMino-2-fluorophenyl)ethanone Property

Melting point:: 76-77 °C(Solv: cyclohexane (110-82-7))
Boiling point:: 295.8±20.0 °C(Predicted)
Density: 1.201±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: crystalline powder
pka: 3.47±0.10(Predicted)
color: Light golden tan

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Safety

HS Code: 2922390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: A634745
Product name: 1-(5-Amino-2-fluorophenyl)ethanone
Packaging: 500mg
Price: $175
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0006196
Product name: 5'-AMINO-2'-FLUOROACETOPHENONE
Purity: 95.00%
Packaging: 250MG
Price: $224.7
Updated: 2021/12/16

Apolloscientific

Product number: PC32127
Product name: 5'-Amino-2'-fluoroacetophenone
Purity: 95%
Packaging: 1g
Price: $80
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-3-Z8
Product name: 5'-Amino-2'-fluoroacetophenone
Packaging: 1g
Price: $88
Updated: 2021/12/16

Apolloscientific

Product number: PC32127
Product name: 5'-Amino-2'-fluoroacetophenone
Purity: 95%
Packaging: 5g
Price: $327
Updated: 2021/12/16

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1-(5-aMino-2-fluorophenyl)ethanone Chemical Properties,Usage,Production

Uses

1-(5-Amino-2-fluorophenyl)ethanone is a useful reactant for the synthesis of 9-arylpurines as a novel class of Enterovirus inhibitors.

Synthesis

79110-05-7

67500-19-0

General procedure for the synthesis of 2-fluoro-5-aminoacetophenone from 1-(2-fluoro-5-nitrophenyl)ethanone: 1-(2-fluoro-5-nitrophenyl)ethanone (0.3 g, 1.64 mmol), iron powder (0.27 g, 4.92 mmol), ammonium chloride (0.17 g, 3.28 mmol), isopropanol (12.8 mL), and water (3.2 mL ) were mixed and reacted for 3 hours. After completion of the reaction, the insoluble precipitate was removed by filtration, the organic layer was extracted with dichloromethane, dried with anhydrous magnesium sulfate, and concentrated in vacuum to obtain a yellow oily crude product. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1:2, Rf=0.3) to afford 2-fluoro-5-aminoacetophenone (0.19 g, 76% yield).

References

[1] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 3, p. 673 - 683
[2] Patent: WO2016/172255, 2016, A1. Location in patent: Page/Page column 96; 97
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1725 - 1728
[4] Patent: EP2147914, 2010, A1. Location in patent: Page/Page column 29
[5] Patent: US2012/15961, 2012, A1. Location in patent: Page/Page column 41

1-(5-aMino-2-fluorophenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-aMino-2-fluorophenyl)ethanone Suppliers

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View Lastest Price from 1-(5-aMino-2-fluorophenyl)ethanone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-(5-Amino-2-fluorophenyl)ethanone 67500-19-0
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-17

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(5-aMino-2-fluorophenyl)ethanone 67500-19-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

67500-19-0, 1-(5-aMino-2-fluorophenyl)ethanoneRelated Search:

1-(5-AMINO-2-FLUOROPHENYL)ETHANONE

Ethanone, 1-(5-aMino-2-fluorophenyl)-

Ethanone, 1-(5-amino-2-fluorophenyl)- (9CI)

1-(5-Amino-2-fluorophenyl)ethan-1-one, 3-Acetyl-4-fluoroaniline

5'-Amino-2'-fluoroecetophenone

1-(5-Amino-2-fluorophenyl)

5'-Amino-2'-fluoroacetophenone 95%

5'-Amino-2'-fluoroacetophenone

67500-19-0

Fluorine series

ACETYLGROUP