Benzofuran, 7-bromo-4-methyl- (9CI)
- Product Name
- Benzofuran, 7-bromo-4-methyl- (9CI)
- CAS No.
- 799766-13-5
- Chemical Name
- Benzofuran, 7-bromo-4-methyl- (9CI)
- Synonyms
- 7-Bromo-4-methylbenzofuran;Benzofuran, 7-bromo-4-methyl-;7-broMo-4-Methyl-1-benzofuran;Benzofuran, 7-bromo-4-methyl- (9CI)
- CBNumber
- CB81065509
- Molecular Formula
- C9H7BrO
- Formula Weight
- 211.06
- MOL File
- 799766-13-5.mol
Benzofuran, 7-bromo-4-methyl- (9CI) Property
- Boiling point:
- 261.5±20.0 °C(Predicted)
- Density
- 1.520±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 3604CZ
- Product name
- 7-Bromo-4-methylbenzofuran
- Packaging
- 250mg
- Price
- $243
- Updated
- 2021/12/16
- Product number
- 3604CZ
- Product name
- 7-Bromo-4-methylbenzofuran
- Packaging
- 1g
- Price
- $539
- Updated
- 2021/12/16
- Product number
- HCH0037438
- Product name
- BENZOFURAN, 7-BROMO-4-METHYL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- CD11055019
- Product name
- 7-Bromo-4-methylbenzofuran
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1753
- Updated
- 2021/12/16
- Product number
- 799766135
- Product name
- 7-Bromo-4-methylbenzofuran
- Packaging
- 5g
- Price
- $1823.1
- Updated
- 2021/12/16
Benzofuran, 7-bromo-4-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis
799766-12-4
799766-13-5
To a 500-mL round-bottomed flask was added 15.6 g of polyphosphoric acid (PPA) and anhydrous chlorobenzene (260 mL). The mixture was heated to reflux and a solution of 1-bromo-2-(2,2-dimethoxyethoxy)-4-methylbenzene (8.11 g, 29.5 mmol) dissolved in chlorobenzene (60 mL) was added slowly and dropwise over 2 hours. The reflux reaction was maintained for 3 hours and then cooled to room temperature. The reaction mixture was filtered through a silica plug and subsequently concentrated. Purification by column chromatography (eluent: 100% hexane) afforded 4.67 g (75% yield) of the target product 7-bromo-4-methyl-benzofuran as a white, waxy solid with a melting point of 32-33 °C. 1H NMR (300 MHz, DMSO-d6) δ: 2.46 (3H, single peak), 7.02 (1H, double peak, J=7.9 Hz), 7.16 ( 1H, double peak, J=2.2 Hz), 7.43 (1H, double peak, J=7.9 Hz), 8.10 (1H, double peak, J=2.2 Hz). Mass spectrum (EI) m/z: 210 ([M+]). Elemental analysis (C9H7BrO) Calculated value: C: 51.22, H: 3.34; measured value: C: 50.83, H: 3.08.
References
[1] Patent: WO2004/103941, 2004, A2. Location in patent: Page 27
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 4, p. 902 - 906
Benzofuran, 7-bromo-4-methyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Benzofuran, 7-bromo-4-methyl- (9CI) Suppliers
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