Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)
- Product Name
- Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)
- CAS No.
- 92398-47-5
- Chemical Name
- Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)
- Synonyms
- Methyl 1-aMinocyclobutane carboxylate HCl;Methyl 1-aMinocyclobutanecarboxylate hydrochloride;Methyl1-aminocyclobutanecarboxylatehydrochloride,95%;methyl 1-aminocyclobutane-1-carboxylate hydrochloride;1-Aminocyclobutanecarboxylicacidmethylesterhydrochloride;Cyclobutanecarboxylic acid, 1-aMino-, Methyl ester, hydrochloride;Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI)
- CBNumber
- CB81066485
- Molecular Formula
- C6H12ClNO2
- Formula Weight
- 165.62
- MOL File
- 92398-47-5.mol
Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI) Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- White
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Air Sensitive
Safety
- HS Code
- 2916200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M331008
- Product name
- Methyl1-AminocyclobutanecarboxylateHydrochloride
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 076605
- Product name
- Methyl 1-aminocyclobutanecarboxylate hydrochloride
- Purity
- 95.0
- Packaging
- 1g
- Price
- $559
- Updated
- 2021/12/16
- Product number
- FC32220
- Product name
- Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride(9CI)
- Packaging
- 500mg
- Price
- $630
- Updated
- 2021/12/16
- Product number
- W9541
- Product name
- Methyl1-aminocyclobutanecarboxylatehydrochloride
- Packaging
- 25g
- Price
- $710
- Updated
- 2021/12/16
- Product number
- CHM0006507
- Product name
- 1-AMINOCYCLOBUTANECARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $882.42
- Updated
- 2021/12/16
Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI) Chemical Properties,Usage,Production
Uses
Used as a primary and secondary intermediate for pharmaceutical and organic synthesis.
Synthesis
67-56-1
22264-50-2
92398-47-5
Acetyl chloride (4.2 ml, 58.6 mmol) was added slowly and dropwise to a stirred solution of 1-aminocyclobutane-1-carboxylic acid (2.7 g, 23.4 mmol) in methanol (40 ml) at 0 °C. The reaction mixture was then warmed to room temperature and stirred continuously for about 12 hours. The reaction progress was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was concentrated under reduced pressure to afford methyl 1-aminocyclobutane-1-carboxylate hydrochloride (3.02 g, yield: 100%) as a white solid. To a stirred solution of 1-aminocyclobutane-1-carboxylic acid hydrochloride (3.02 g, 23.4 mmol) in tetrahydrofuran (THF, 40 ml) at 0 °C was added triethylamine (N(Et)3, 9.6 ml, 69.6 mmol) and di-tert-butyl dicarbonate ((Boc)2O, 6.4 ml, 23.8 mmol). The reaction mixture was then warmed to room temperature and stirred continuously for about 12 hours. The reaction progress was monitored by TLC. Upon completion of the reaction, saturated ammonium chloride (NH4Cl) solution was added and extracted with ethyl acetate (EtOAc, 2 x 100 mL). The combined organic phases were washed with brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the crude product. Purification by fast column chromatography using ethyl acetate-hexane (3:7) as eluent gave the target product (5.32 g, yield: 100%) as an oil. 1H NMR (300 MHz, DMSO-d6): δ 7.64 (s, 1H), 3.60 (s, 3H), 2.44-2.38 (m, 2H), 2.14-2.04 (m, 2H), 1.88-1.80 (m, 2H), 1.36 (s, 9H).
References
[1] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 80-81
[2] Journal of the American Chemical Society, 1997, vol. 119, # 49, p. 11807 - 11816
[3] Patent: CN104230766, 2017, B. Location in patent: Paragraph 0382; 0383; 0384
[4] Patent: CN104341351, 2018, B. Location in patent: Paragraph 0356-0359
[5] Journal of Medicinal Chemistry, 1984, vol. 27, # 12, p. 1663 - 1668
Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI) manufacturers
- Product
- Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI) 92398-47-5
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10
- Product
- Cyclobutanecarboxylic acid, 1-amino-, methyl ester, hydrochloride (9CI) 92398-47-5
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10